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Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis.
Loginovic P, Wang F, Li J, Ferrat L, Mirshahi UL, Rao HS, Petzold A, Tyrrell J, Green HD, Weedon MN, Ganna A, Tuomi T, Carey DJ; UKBB Eye & Vision Consortium; FinnGen; Geisinger-Regeneron DiscovEHR Collaboration; Oram RA, Braithwaite T. Loginovic P, et al. Nat Commun. 2024 Feb 28;15(1):1415. doi: 10.1038/s41467-024-44917-9. Nat Commun. 2024. PMID: 38418465 Free PMC article.
Optic radiations representing different eccentricities age differently.
Kruper J, Benson NC, Caffarra S, Owen J, Wu Y, Lee AY, Lee CS, Yeatman JD, Rokem A; UK Biobank Eye and Vision Consortium. Kruper J, et al. Hum Brain Mapp. 2023 Jun 1;44(8):3123-3135. doi: 10.1002/hbm.26267. Epub 2023 Mar 10. Hum Brain Mapp. 2023. PMID: 36896869 Free PMC article.
Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in the U.K. Biobank dataset (UKBB; N = 5382; age 45-81). We use pyAFQ to characterize white matter tissue properties in parts of the OR th …
Here, we perform white matter tractometry using pyAFQ on a large sample of diffusion MRI (dMRI) data from subjects with healthy vision in th …
UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases.
Warwick AN, Curran K, Hamill B, Stuart K, Khawaja AP, Foster PJ, Lotery AJ, Quinn M, Madhusudhan S, Balaskas K, Peto T; UKBB Eye and Vision Consortium. Warwick AN, et al. Eye (Lond). 2023 Jul;37(10):2109-2116. doi: 10.1038/s41433-022-02298-7. Epub 2022 Nov 3. Eye (Lond). 2023. PMID: 36329166 Free PMC article.
BACKGROUND/OBJECTIVES: This study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009-2010, and to characterise individuals with retinal features suggestive of age-related macular degene …
BACKGROUND/OBJECTIVES: This study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participant …
Spectral-Domain Optical Coherence Tomography Imaging in 67 321 Adults: Associations with Macular Thickness in the UK Biobank Study.
Patel PJ, Foster PJ, Grossi CM, Keane PA, Ko F, Lotery A, Peto T, Reisman CA, Strouthidis NG, Yang Q; UK Biobank Eyes and Vision Consortium. Patel PJ, et al. Ophthalmology. 2016 Apr;123(4):829-40. doi: 10.1016/j.ophtha.2015.11.009. Epub 2015 Dec 30. Ophthalmology. 2016. PMID: 26746598
RESULTS: The SD OCT scans of 67 321 subjects were available for analysis, with 32 062 people with at least 1 eye meeting the inclusion criteria. There were 17 274 women and 14 788 men, with a mean (standard deviation [SD]) age of 55.2 (8.2) years. ...CONCLUSIONS: We report …
RESULTS: The SD OCT scans of 67 321 subjects were available for analysis, with 32 062 people with at least 1 eye meeting the inclusio …
Optical Coherence Tomography in the UK Biobank Study - Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies.
Keane PA, Grossi CM, Foster PJ, Yang Q, Reisman CA, Chan K, Peto T, Thomas D, Patel PJ; UK Biobank Eye Vision Consortium. Keane PA, et al. PLoS One. 2016 Oct 7;11(10):e0164095. doi: 10.1371/journal.pone.0164095. eCollection 2016. PLoS One. 2016. PMID: 27716837 Free PMC article.
RESULTS: 67,321 participants (134,642 eyes) in UK Biobank underwent OCT imaging of both eyes as part of the ocular module. 134,611 images were successfully processed with 31 images failing segmentation analysis due to corrupted OCT files or withdrawal of subject consent for UK …
RESULTS: 67,321 participants (134,642 eyes) in UK Biobank underwent OCT imaging of both eyes as part of the ocular module. 134,611 images we …