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Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.
J Natl Cancer Inst. 2023 Jun 8;115(6):712-732. doi: 10.1093/jnci/djad043.
J Natl Cancer Inst. 2023.
PMID: 36929942
Free PMC article.
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, Bueno-de-Mesquita HB, Fuchs CS, Gross MD, Jacobs EJ, Lacroix AZ, Petersen GM, Stolzenberg-Solomon RZ, Zheng W, Albanes D, Amundadottir L, Bamlet WR, Barricarte A, Bingham SA, Boeing H, Boutron-Ruault MC, Buring JE, Chanock SJ, Clipp S, Gaziano JM, Giovannucci EL, Hankinson SE, Hartge P, Hoover RN, Hunter DJ, Hutchinson A, Jacobs KB, Kraft P, Lynch SM, Manjer J, Manson JE, McTiernan A, McWilliams RR, Mendelsohn JB, Michaud DS, Palli D, Rohan TE, Slimani N, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Virtamo J, Wolpin BM, Yu K, Zeleniuch-Jacquotte A, Patel AV; Pancreatic Cancer Cohort Consortium (PanScan).
Arslan AA, et al.
Arch Intern Med. 2010 May 10;170(9):791-802. doi: 10.1001/archinternmed.2010.63.
Arch Intern Med. 2010.
PMID: 20458087
Free PMC article.
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Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
Kim J, Yuan C, Amundadottir LT, Wolpin BM; Pancreatic Cancer Cohort Consortium (PanScan); Klein AP; Pancreatic Cancer Case–Control Consortium (PanC4); Risch HA, Kraft P.
Kim J, et al.
Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1242-1248. doi: 10.1158/1055-9965.EPI-23-0009.
Cancer Epidemiol Biomarkers Prev. 2023.
PMID: 37342060
Free PMC article.
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Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
Chen H, Majumdar A, Wang L, Kar S, Brown KM, Feng H, Turman C, Dennis J, Easton D, Michailidou K, Simard J; Breast Cancer Association Consortium (BCAC); Bishop T, Cheng IC, Huyghe JR, Schmit SL; Colorectal Transdisciplinary Study (CORECT); Colon Cancer Family Registry Study (CCFR); Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); O'Mara TA, Spurdle AB; Endometrial Cancer Association Consortium (ECAC); Gharahkhani P, Schumacher J, Jankowski J, Gockel I; Esophageal Cancer GWAS Consortium; Bondy ML, Houlston RS, Jenkins RB, Melin B; Glioma International Case Control Consortium (GICC); Lesseur C, Ness AR, Diergaarde B, Olshan AF; Head-Neck Cancer GWAS Consortium; Amos CI, Christiani DC, Landi MT, McKay JD; International Lung Cancer Consortium (ILCCO); Brossard M, Iles MM, Law MH, MacGregor S; Melanoma GWAS Consortium; Beesley J, Jones MR, Tyrer J, Winham SJ; Ovarian Cancer Association Consortium (OCAC); Klein AP, Petersen G, Li D, Wolpin BM; Pancreatic Cancer Case-Control Consortium (PANC4); Pancreatic Cancer Cohort Consortium (PanScan); Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR; PRACTICAL consortium; CRUK; BPC3; CAPS; PEGASUS; Brennan P, Chanock SJ, Gaborieau…
See abstract for full author list ➔
Chen H, et al.
HGG Adv. 2021 Jul 8;2(3):100041. doi: 10.1016/j.xhgg.2021.100041. Epub 2021 Jun 12.
HGG Adv. 2021.
PMID: 34355204
Free PMC article.
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Predictive Prioritization of Enhancers Associated with Pancreas Disease Risk.
Wang L, Baek S, Prasad G, Wildenthal J, Guo K, Sturgill D, Truongvo T, Char E, Pegoraro G, McKinnon K; Pancreatic Cancer Cohort Consortium; Pancreatic Cancer Case-Control Consortium; Hoskins JW, Amundadottir LT, Arda HE.
Wang L, et al.
bioRxiv [Preprint]. 2024 Sep 13:2024.09.07.611794. doi: 10.1101/2024.09.07.611794.
bioRxiv. 2024.
PMID: 39314336
Free PMC article.
Preprint.
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Allelic effects on KLHL17 expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33.
Connelly KE, Hullin K, Abdolalizadeh E, Zhong J, Eiser D, O'Brien A, Collins I, Sudipto Das, Duncan G; Pancreatic Cancer Cohort Consortium; Pancreatic Cancer Case-Control Consortium; Chanock SJ, Stolzenberg-Solomon RZ, Klein AP, Wolpin BM, Hoskins JW, Andresson T, Smith JP, Amundadottir LT.
Connelly KE, et al.
medRxiv [Preprint]. 2024 Sep 16:2024.09.16.24313748. doi: 10.1101/2024.09.16.24313748.
medRxiv. 2024.
PMID: 39371158
Free PMC article.
Preprint.
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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang YD, Hurson AN, Zhang H, Choudhury PP, Easton DF, Milne RL, Simard J, Hall P, Michailidou K, Dennis J, Schmidt MK, Chang-Claude J, Gharahkhani P, Whiteman D, Campbell PT, Hoffmeister M, Jenkins M, Peters U, Hsu L, Gruber SB, Casey G, Schmit SL, O'Mara TA, Spurdle AB, Thompson DJ, Tomlinson I, De Vivo I, Landi MT, Law MH, Iles MM, Demenais F, Kumar R, MacGregor S, Bishop DT, Ward SV, Bondy ML, Houlston R, Wiencke JK, Melin B, Barnholtz-Sloan J, Kinnersley B, Wrensch MR, Amos CI, Hung RJ, Brennan P, McKay J, Caporaso NE, Berndt SI, Birmann BM, Camp NJ, Kraft P, Rothman N, Slager SL, Berchuck A, Pharoah PDP, Sellers TA, Gayther SA, Pearce CL, Goode EL, Schildkraut JM, Moysich KB, Amundadottir LT, Jacobs EJ, Klein AP, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Wolpin BM, Li D, Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR, Al Olama AA, Purdue MP, Scelo G, Dalgaard MD, Greene MH, Grotmol T, Kanetsky PA, McGlynn KA, Nathanson KL, Turnbull C, Wiklund F; Breast Cancer Association Consortium (BCAC); Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON); Colon Cancer Family Registry (CCFR); Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT); Endom…
See abstract for full author list ➔
Zhang YD, et al.
Nat Commun. 2020 Jul 3;11(1):3353. doi: 10.1038/s41467-020-16483-3.
Nat Commun. 2020.
PMID: 32620889
Free PMC article.
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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M; CVD50 consortium; Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sacerdote C, Salomaa V, Sánchez MJ, Sattar N, Sharp SJ, Sims R, Slimani N, Smith JA, Thompson DJ, Trompet S, Tumino R, van der A DL, van der Schouw YT, Virtamo J, Walker M, Walt…
See abstract for full author list ➔
Scott RA, et al.
Sci Transl Med. 2016 Jun 1;8(341):341ra76. doi: 10.1126/scitranslmed.aad3744.
Sci Transl Med. 2016.
PMID: 27252175
Free PMC article.
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