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29 results

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Page 1
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis.
Zhang Y, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, Lambert AW, Thiru P, Keys HR, Khan M, Hofree M, Wilson MM, Yedier-Bayram O, Lack NA, Onder TT, Bagci-Onder T, Tyler M, Tirosh I, Regev A, Lees JA, Weinberg RA. Zhang Y, et al. Among authors: onder tt. Nat Cell Biol. 2022 Apr;24(4):554-564. doi: 10.1038/s41556-022-00877-0. Epub 2022 Apr 11. Nat Cell Biol. 2022. PMID: 35411083 Free PMC article.
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Ozyerli-Goknar E, Kala EY, Aksu AC, Bulut I, Cingöz A, Nizamuddin S, Biniossek M, Seker-Polat F, Morova T, Aztekin C, Kung SHY, Syed H, Tuncbag N, Gönen M, Philpott M, Cribbs AP, Acilan C, Lack NA, Onder TT, Timmers HTM, Bagci-Onder T. Ozyerli-Goknar E, et al. Among authors: onder tt. Cell Commun Signal. 2023 Nov 16;21(1):328. doi: 10.1186/s12964-023-01335-6. Cell Commun Signal. 2023. PMID: 37974198 Free PMC article.
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming.
Sevinç K, Sevinç GG, Cavga AD, Philpott M, Kelekçi S, Can H, Cribbs AP, Yıldız AB, Yılmaz A, Ayar ES, Arabacı DH, Dunford JE, Ata D, Sigua LH, Qi J, Oppermann U, Onder TT. Sevinç K, et al. Among authors: onder tt. Stem Cell Reports. 2022 Dec 13;17(12):2629-2642. doi: 10.1016/j.stemcr.2022.10.005. Epub 2022 Nov 3. Stem Cell Reports. 2022. PMID: 36332631 Free PMC article.
EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities.
Yedier-Bayram O, Gokbayrak B, Kayabolen A, Aksu AC, Cavga AD, Cingöz A, Kala EY, Karabiyik G, Günsay R, Esin B, Morova T, Uyulur F, Syed H, Philpott M, Cribbs AP, Kung SHY, Lack NA, Onder TT, Bagci-Onder T. Yedier-Bayram O, et al. Among authors: onder tt. Cell Death Dis. 2022 Aug 16;13(8):710. doi: 10.1038/s41419-022-05146-4. Cell Death Dis. 2022. PMID: 35973998 Free PMC article.
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.
Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs AP, Philpott M, Uyulur F, Morova T, Dunford JE, Göklemez S, Arı Ş, Oppermann U, Önder TT. Ebrahimi A, et al. Among authors: onder tt. Nat Chem Biol. 2019 May;15(5):519-528. doi: 10.1038/s41589-019-0264-z. Epub 2019 Apr 8. Nat Chem Biol. 2019. PMID: 30962627 Free PMC article.
29 results