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Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.
Mataix-Cols D, Hansen B, Mattheisen M, Karlsson EK, Addington AM, Boberg J, Djurfeldt DR, Halvorsen M, Lichtenstein P, Solem S, Lindblad-Toh K; Nordic OCD and Related Disorders Consortium (NORDiC); Haavik J, Kvale G, Rück C, Crowley JJ. Mataix-Cols D, et al. Am J Med Genet B Neuropsychiatr Genet. 2020 Jan;183(1):38-50. doi: 10.1002/ajmg.b.32756. Epub 2019 Aug 19. Am J Med Genet B Neuropsychiatr Genet. 2020. PMID: 31424634 Free PMC article.
We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases …
We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the …
Genome-wide association study identifies new loci associated with OCD.
Strom NI, Halvorsen MW, Tian C, Rück C, Kvale G, Hansen B, Bybjerg-Grauholm J, Grove J, Boberg J, Nissen JB, Damm Als T, Werge T, de Schipper E, Fundin B, Hultman C, Höffler KD, Pedersen N, Sandin S, Bulik C, Landén M, Karlsson E, Hagen K, Lindblad-Toh K; Nordic OCD and Related Disorders Consortium (NORDiC); 23andMe Research Team; PGC TS/OCD working group; Hougaard DM, Meier SM, Hellard SL, Mors O, Børglum AD, Haavik J, Hinds DA, Mataix-Cols D, Crowley JJ, Mattheisen M. Strom NI, et al. medRxiv [Preprint]. 2024 Mar 8:2024.03.06.24303776. doi: 10.1101/2024.03.06.24303776. medRxiv. 2024. PMID: 38496634 Free PMC article. Preprint.
A substantial increase in sample size will likely lead to further identification of SNPs, genes, and biological pathways mediating the susceptibility to OCD. We conducted a GWAS meta-analysis with a 2-3-fold increase in case sample size (OCD cases: N = 37,015, contr …
A substantial increase in sample size will likely lead to further identification of SNPs, genes, and biological pathways mediating the susce …
A cross ancestry genetic study of psychiatric disorders from India.
Holla B, Mahadevan J, Ganesh S, Sud R, Janardhanan M, Balachander S, Strom N, Mattheisen M, Sullivan PF, Huang H, Zandi P, Benegal V, Reddy YJ, Jain S; cVEDA collaborators; ADBS-CBM consortium; iPSYCH OCD consortium; NORDiC OCD & Related Disorders Consortium; Purushottam M, Viswanath B. Holla B, et al. medRxiv [Preprint]. 2024 Apr 27:2024.04.25.24306377. doi: 10.1101/2024.04.25.24306377. medRxiv. 2024. PMID: 38712191 Free PMC article. Preprint.
PGS were calculated from the largest available European discovery GWAS summary statistics for BD, OCD, and externalizing traits using two Bayesian methods that incorporate local linkage disequilibrium structures (PGS-CS-auto) and functional genomic annotations (SBayesRC). …
PGS were calculated from the largest available European discovery GWAS summary statistics for BD, OCD, and externalizing traits using …
A burden of rare copy number variants in obsessive-compulsive disorder.
Halvorsen MW, de Schipper E, Bäckman J, Strom NI, Hagen K; Nordic OCD and Related Disorders Consortium (NORDiC); Lindblad-Toh K, Karlsson EK, Pedersen NL, Wallert J, Bulik CM, Fundín B, Landén M, Kvale G, Hansen B, Haavik J, Mattheisen M, Rück C, Mataix-Cols D, Crowley JJ. Halvorsen MW, et al. Mol Psychiatry. 2024 Oct 27. doi: 10.1038/s41380-024-02763-7. Online ahead of print. Mol Psychiatry. 2024. PMID: 39463448
The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. ...The results demonstrate a contribution of rare CNVs to OCD risk, and suggest that studies of rare coding variation in OCD would …
The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. ...Th …