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1964 1
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1974 10
1975 2
1976 8
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1980 36
1981 57
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1999 712
2000 850
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2002 900
2003 887
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17,128 results

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Page 1
Showing results for microm o
Search for Miro MO instead (1 results)
H(2)O(2) and ethanol act synergistically to gate ryanodine receptor/calcium-release channel.
Oba T, Ishikawa T, Murayama T, Ogawa Y, Yamaguchi M. Oba T, et al. Am J Physiol Cell Physiol. 2000 Nov;279(5):C1366-74. doi: 10.1152/ajpcell.2000.279.5.C1366. Am J Physiol Cell Physiol. 2000. PMID: 11029284 Free article.
Increase of H(2)O(2) to 100 microM caused a further increase in channel activity. Application of 4.4 mM ethanol to 10 microM H(2)O(2)-treated RyRs activated channel activity. Exposure to 10 or 100 microM H(2)O(2) alone, however, failed to …
Increase of H(2)O(2) to 100 microM caused a further increase in channel activity. Application of 4.4 mM ethanol to 10 micro …
Evidence for P(2)-purinoceptors contribution in H(2)O(2)-induced contraction of rat aorta in the absence of endothelium.
Shen JZ, Zheng XF, Kwan CY. Shen JZ, et al. Cardiovasc Res. 2000 Aug 18;47(3):574-85. doi: 10.1016/s0008-6363(00)00123-1. Cardiovasc Res. 2000. PMID: 10963730
RESULTS: Both H(2)O(2) and ATP induced transient phasic contractions in a concentration-dependent manner (1-1000 microM). ...On the other hand, both H(2)O(2) (30 microM) and ATP (100 microM)-induced phasic contractions were also attenuated, to d …
RESULTS: Both H(2)O(2) and ATP induced transient phasic contractions in a concentration-dependent manner (1-1000 microM). ...O …
4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells.
Jin GZ, Quan HJ, Koyanagi J, Takeuchi K, Miura Y, Komada F, Saito S. Jin GZ, et al. Cancer Lett. 2005 Jan 31;218(1):15-20. doi: 10.1016/j.canlet.2004.07.025. Cancer Lett. 2005. PMID: 15639336
Among 4'-O-alkylaloenins 2-17, 4'-O-tetradecylaloenin 14 was the most cytotoxic to both on HCT 116 cells (IC50 value: 5.3+/-2.3 microM) and Hep G2 cells (IC50 value: 4.0+/-0.6 microM). Also among 4'-O-alkylaloenin sulfates 21-29, 4'-O-dod …
Among 4'-O-alkylaloenins 2-17, 4'-O-tetradecylaloenin 14 was the most cytotoxic to both on HCT 116 cells (IC50 value: 5.3+/-2. …
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Griffin RJ, Arris CE, Bleasdale C, Boyle FT, Calvert AH, Curtin NJ, Dalby C, Kanugula S, Lembicz NK, Newell DR, Pegg AE, Golding BT. Griffin RJ, et al. J Med Chem. 2000 Nov 2;43(22):4071-83. doi: 10.1021/jm000961o. J Med Chem. 2000. PMID: 11063604
Simple O(6)-alkyl- and O(6)-cycloalkylguanines were weak AGT inactivators compared with O(6)-allylguanine (IC(50) = 8.5 +/- 0.6 microM) with IC(50) values ranging from 100 to 1000 microM. The introduction of substituents at C-2 of the allyl grou …
Simple O(6)-alkyl- and O(6)-cycloalkylguanines were weak AGT inactivators compared with O(6)-allylguanine (IC(50) = 8.5 …
Heptachlor and o-p'DDT effects on protein kinase activities associated with human placenta particulate fractions.
Magnarelli G, Souza MS, de D'Angelo AM. Magnarelli G, et al. J Biochem Mol Toxicol. 2009 May-Jun;23(3):185-92. doi: 10.1002/jbt.20277. J Biochem Mol Toxicol. 2009. PMID: 19526567
In particulate fractions, total serine/threonine kinase activity was increased by 10 microM HC and o-p' DDT (59% and 82%, respectively). Maximum eightfold increase was observed with 10 microM o-p' DDT on protein kinase A activity. ...Exposition to 100 …
In particulate fractions, total serine/threonine kinase activity was increased by 10 microM HC and o-p' DDT (59% and 82%, resp …
Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.
Wedge SR, Porteus JK, May BL, Newlands ES. Wedge SR, et al. Br J Cancer. 1996 Feb;73(4):482-90. doi: 10.1038/bjc.1996.85. Br J Cancer. 1996. PMID: 8595163 Free PMC article.
In multiple dosing studies two colorectal cell lines (Mawi and LS174T) were treated with temozolomide or BCNU at 24 h intervals for up to 5 days, with or without either 100 microM O(6)-BG for 1 h or 1 microM O(6)-BG for 24 h, commencing 1 h before alky …
In multiple dosing studies two colorectal cell lines (Mawi and LS174T) were treated with temozolomide or BCNU at 24 h intervals for up to 5 …
Synthesis and evaluation of the antiproliferative effects of 1-O-hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D- glucopyranosyl)-sn-glycerol and 1-O-hexadecyl-2-O-methyl-3-0- (2'-amino-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol on epithelial cancer cell growth.
Erukulla RK, Zhou X, Samadder P, Arthur G, Bittman R. Erukulla RK, et al. J Med Chem. 1996 Mar 29;39(7):1545-8. doi: 10.1021/jm950928f. J Med Chem. 1996. PMID: 8691486
Two ether glucosyl diglyceride analogs were synthesized, and their antiproliferative activity against four epithelial cancer cell lines was evaluated. 1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D- glucopyranosyl)-sn-glycerol (4) was synthesized …
Two ether glucosyl diglyceride analogs were synthesized, and their antiproliferative activity against four epithelial cancer cell lines was …
H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways.
Kwon SH, Pimentel DR, Remondino A, Sawyer DB, Colucci WS. Kwon SH, et al. J Mol Cell Cardiol. 2003 Jun;35(6):615-21. doi: 10.1016/s0022-2828(03)00084-1. J Mol Cell Cardiol. 2003. PMID: 12788379
Adult rat ventricular myocytes were exposed to H(2)O(2) over a broad concentration range (10-1000 microM). Low concentrations of H(2)O(2) (10-30 microM) increased protein synthesis without affecting survival. Higher concentrations of H(2)O(2) (1 …
Adult rat ventricular myocytes were exposed to H(2)O(2) over a broad concentration range (10-1000 microM). Low concentrations …
Chitin synthase 2 inhibitory activity of O-methyl pisiferic acid and 8,20-dihydroxy-9(11),13-abietadien-12-one, isolated from Chamaecyparis pisifera.
Kang TH, Hwang EI, Yun BS, Shin CS, Kim SU. Kang TH, et al. Biol Pharm Bull. 2008 Apr;31(4):755-9. doi: 10.1248/bpb.31.755. Biol Pharm Bull. 2008. PMID: 18379078 Free article.
These compounds inhibited chitin synthase 2 of Saccharomyces cerevisiae with the IC50 values of 5.8 and 226.4 microM, respectively. Especially, O-methyl pisiferic acid showed 15.3-fold stronger inhibitory activity than polyoxin D (IC50=88.6 microM), a well-kn …
These compounds inhibited chitin synthase 2 of Saccharomyces cerevisiae with the IC50 values of 5.8 and 226.4 microM, respectively. E …
The inhibition of catechol-O-methyltransferase by 2,3-dihydroxypyridine.
Raxworthy MJ, Youde IR, Gulliver PA. Raxworthy MJ, et al. Biochem Pharmacol. 1983 Apr 15;32(8):1361-4. doi: 10.1016/0006-2952(83)90447-1. Biochem Pharmacol. 1983. PMID: 6860355
Despite its structural similarity to catechol, 2,3-dihydroxypyridine is not a substrate but a "dead-end" inhibitor of purified pig liver catechol-O-methyltransferase. It inhibits the methylation of 3,4-dihydroxyphenylacetic acid competitively with an inhibitor constant of …
Despite its structural similarity to catechol, 2,3-dihydroxypyridine is not a substrate but a "dead-end" inhibitor of purified pig liver cat …
17,128 results
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