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Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P; LUNG SAFE Investigators and the ESICM Trials Group. Maddali MV, et al. Lancet Respir Med. 2022 Apr;10(4):367-377. doi: 10.1016/S2213-2600(21)00461-6. Epub 2022 Jan 10. Lancet Respir Med. 2022. PMID: 35026177 Free PMC article.
In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multinational, observational ARDS cohort, we applied a custom classifier model (with fewer variables than the primary model) to determine the prog …
In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multin …
Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study.
Rezoagli E, McNicholas BA, Madotto F, Pham T, Bellani G, Laffey JG; LUNG SAFE Investigators, the ESICM Trials Group. Rezoagli E, et al. Ann Intensive Care. 2022 May 21;12(1):42. doi: 10.1186/s13613-022-01015-7. Ann Intensive Care. 2022. PMID: 35596885 Free PMC article.
BACKGROUND: The impact of underlying comorbidities on the clinical presentation, management and outcomes in patients with ARDS is poorly understood and deserves further investigation. OBJECTIVES: We examined these issue in patients with ARDS enrolled in the Large observati …
BACKGROUND: The impact of underlying comorbidities on the clinical presentation, management and outcomes in patients with ARDS is poorly und …
Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.
Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group. Cortegiani A, et al. Crit Care. 2018 Jun 12;22(1):157. doi: 10.1186/s13054-018-2079-9. Crit Care. 2018. PMID: 29895331 Free PMC article.
METHODS: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an internatio …
METHODS: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understan …
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study.
Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Madotto F, et al. Crit Care. 2020 Mar 31;24(1):125. doi: 10.1186/s13054-020-2826-6. Crit Care. 2020. PMID: 32234077 Free PMC article.
We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. METHODS: In this secondary analysis of the LUNG SAFE study, we wished to deter …
We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respi …
Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study.
Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Madotto F, et al. Intensive Care Med. 2018 May;44(5):564-577. doi: 10.1007/s00134-018-5152-6. Epub 2018 Apr 9. Intensive Care Med. 2018. PMID: 29632996
METHODS: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. ...
METHODS: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus …
Patterns of Use of Adjunctive Therapies in Patients With Early Moderate to Severe ARDS: Insights From the LUNG SAFE Study.
Duggal A, Rezoagli E, Pham T, McNicholas BA, Fan E, Bellani G, Rubenfeld G, Pesenti AM, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Duggal A, et al. Chest. 2020 Jun;157(6):1497-1505. doi: 10.1016/j.chest.2020.01.041. Epub 2020 Feb 20. Chest. 2020. PMID: 32088180 Free article.

However, their application in clinical practice remains inconsistent. RESEARCH QUESTION: We wished to determine the frequency and patterns of use of adjunctive strategies in patients with moderate to severe ARDS (Pao(2)/Fio(2) [P/F ratio] < 150) enrolled into the Large

…
However, their application in clinical practice remains inconsistent. RESEARCH QUESTION: We wished to determine the frequency and pat …
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.
Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group. Laffey JG, et al. Intensive Care Med. 2016 Dec;42(12):1865-1876. doi: 10.1007/s00134-016-4571-5. Epub 2016 Oct 18. Intensive Care Med. 2016. PMID: 27757516
METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a conve …
METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an …
Patterns and Impact of Arterial CO(2) Management in Patients With Acute Respiratory Distress Syndrome: Insights From the LUNG SAFE Study.
Madotto F, Rezoagli E, McNicholas BA, Pham T, Slutsky AS, Bellani G, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Madotto F, et al. Chest. 2020 Nov;158(5):1967-1982. doi: 10.1016/j.chest.2020.05.605. Epub 2020 Jun 24. Chest. 2020. PMID: 32589951
BACKGROUND: Considerable variability exists regarding CO(2) management in early ARDS, with the impact of arterial CO(2) tension on management and outcomes poorly understood. RESEARCH QUESTION: To determine the prevalence and impact of hypocapnia and hypercapnia on the mana …
BACKGROUND: Considerable variability exists regarding CO(2) management in early ARDS, with the impact of arterial CO(2) tension on managemen …
Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study.
McNicholas BA, Madotto F, Pham T, Rezoagli E, Masterson CH, Horie S, Bellani G, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. McNicholas BA, et al. Eur Respir J. 2019 Oct 17;54(4):1900609. doi: 10.1183/13993003.00609-2019. Print 2019 Oct. Eur Respir J. 2019. PMID: 31346004 Free article.
RATIONALE: We wished to determine the influence of sex on the management and outcomes in acute respiratory distress syndrome (ARDS) patients in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE). METHODS: We …
RATIONALE: We wished to determine the influence of sex on the management and outcomes in acute respiratory distress syndrome (ARDS) patients …
11 results