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Page 1
Showing results for hair eb
Search for Hayir EB instead (1 results)
Hair cell-specific Myo15 promoter-mediated gene therapy rescues hearing in DFNB9 mouse model.
Wang H, Xun M, Tang H, Zhao J, Hu S, Zhang L, Lv J, Wang D, Chen Y, Liu J, Li GL, Wang W, Shu Y, Li H. Wang H, et al. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102135. doi: 10.1016/j.omtn.2024.102135. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38404504 Free PMC article.
In this study, we evaluated the expression efficiency and specificity of transgene delivered by AAV-PHP.eB under the inner ear sensory cell-specific Myo15 promoter. Compared with the ubiquitous CAG promoter, the Myo15 promoter initiates efficient expression of the GFP fluo …
In this study, we evaluated the expression efficiency and specificity of transgene delivered by AAV-PHP.eB under the inner ear sensor …
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Cohen JN, et al. Sci Immunol. 2024 Jan 5;9(91):eadh0152. doi: 10.1126/sciimmunol.adh0152. Epub 2024 Jan 5. Sci Immunol. 2024. PMID: 38181095 Free PMC article.
Selective depletion of skin T(regs) resulted in T cell-mediated inflammation of hair follicles (HFs). Suppression did not rely on CTLA-4, but instead on high-affinity interleukin-2 (IL-2) receptor expression by skin T(regs), functioning exclusively in a cell-extrinsic mann …
Selective depletion of skin T(regs) resulted in T cell-mediated inflammation of hair follicles (HFs). Suppression did not rely on CTL …
Clinical Benefits of Baricitinib Therapy According to Scalp Hair Regrowth in Patients with Severe Alopecia Areata.
Senna MM, Kwon O, Piraccini BM, Sinclair R, Ball S, Ding Y, Chen YF, Dutronc Y, King B. Senna MM, et al. Dermatol Ther (Heidelb). 2023 Dec;13(12):3209-3220. doi: 10.1007/s13555-023-01063-2. Epub 2023 Nov 22. Dermatol Ther (Heidelb). 2023. PMID: 37991697 Free PMC article.
Clinical outcomes were assessed using the Severity of Alopecia Tool (SALT) and Clinician-Reported Outcome (ClinRO) for Eyebrow (EB) and Eyelash (EL) hair. Secondary measures included the Hospital Anxiety and Depression Scale and Skindex-16 adapted for alopecia areat …
Clinical outcomes were assessed using the Severity of Alopecia Tool (SALT) and Clinician-Reported Outcome (ClinRO) for Eyebrow (EB) a …
Distributional comparison of different AAV vectors after unilateral cochlear administration.
Han S, Xu Z, Wang S, Tang H, Hu S, Wang H, Guan G, Shu Y. Han S, et al. Gene Ther. 2024 Mar;31(3-4):154-164. doi: 10.1038/s41434-023-00431-z. Epub 2023 Dec 14. Gene Ther. 2024. PMID: 38097651
This study compares transgene expression and biodistribution of AAV1, AAV2, Anc80L65, AAV9, AAV-PHP.B, and AAV-PHP.eB after round window membrane (RWM) injection in neonatal mice. The highest virus concentration was detected in the injected cochlea. AAV2, Anc80L65, AAV9, A …
This study compares transgene expression and biodistribution of AAV1, AAV2, Anc80L65, AAV9, AAV-PHP.B, and AAV-PHP.eB after round win …
Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.
Griffin DR, Archang MM, Kuan CH, Weaver WM, Weinstein JS, Feng AC, Ruccia A, Sideris E, Ragkousis V, Koh J, Plikus MV, Di Carlo D, Segura T, Scumpia PO. Griffin DR, et al. Nat Mater. 2021 Apr;20(4):560-569. doi: 10.1038/s41563-020-00844-w. Epub 2020 Nov 9. Nat Mater. 2021. PMID: 33168979 Free PMC article.
Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened material degradation in vivo and imparted significant tissue regeneration to healed cutaneous wounds, including increased tensile strength and …
Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened mater …
Engineering of the AAV-Compatible Hair Cell-Specific Small-Size Myo15 Promoter for Gene Therapy in the Inner Ear.
Hu SW, Lv J, Wang Z, Tang H, Wang H, Wang F, Wang D, Zhang J, Zhang L, Cao Q, Chen Y, Gao Z, Han Y, Wang W, Li GL, Shu Y, Li H. Hu SW, et al. Research (Wash D C). 2024 Apr 25;7:0341. doi: 10.34133/research.0341. eCollection 2024. Research (Wash D C). 2024. PMID: 38665848 Free PMC article.
Through this strategy, we truncated a native promoter for Myo15 expression in hair cells (HCs) in the inner ear, from 1,611 bp down to 1,157 bp, and further down to 956 bp. Under the control of these 2 promoters, green fluorescent protein packaged in AAV-PHP.eB was …
Through this strategy, we truncated a native promoter for Myo15 expression in hair cells (HCs) in the inner ear, from 1,611 bp down t …
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Gao X, et al. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. Nature. 2018. PMID: 29258297 Free PMC article.
Injection of Cas9-guide RNA-lipid complexes targeting the Tmc1(Bth) allele into the cochlea of neonatal Tmc1(Bth/+) mice substantially reduced progressive hearing loss. We observed higher hair cell survival rates and lower auditory brainstem response thresholds in injected …
Injection of Cas9-guide RNA-lipid complexes targeting the Tmc1(Bth) allele into the cochlea of neonatal Tmc1(Bth/+) mice substantially reduc …
Long COVID syndrome: An unfolding enigma.
Sharma SK, Mohan A, Upadhyay V. Sharma SK, et al. Indian J Med Res. 2024 Jun;159(6):585-600. doi: 10.25259/IJMR_1449_23. Indian J Med Res. 2024. PMID: 39382470 Free PMC article. Review.
Risk factors for long COVID include older age, female gender, multiple co-morbidities including diabetes mellitus, prior chronic respiratory illnesses, hospitalized patients with severe disease, especially receiving assisted ventilation, high viral load, reactivation of Epstein B …
Risk factors for long COVID include older age, female gender, multiple co-morbidities including diabetes mellitus, prior chronic respiratory …
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing.
Zheng Z, Li G, Cui C, Wang F, Wang X, Xu Z, Guo H, Chen Y, Tang H, Wang D, Huang M, Chen ZY, Huang X, Li H, Li GL, Hu X, Shu Y. Zheng Z, et al. Signal Transduct Target Ther. 2022 Mar 14;7(1):79. doi: 10.1038/s41392-022-00893-4. Signal Transduct Target Ther. 2022. PMID: 35283480 Free PMC article.
We then injected a newly developed AAV vector (AAV-PHP.eB) based CasRx into the inner ears of neonatal Bth mice, and we found that Tmc1(Bth) was reduced by 70.2% in 2 weeks with few off-target effects in the whole transcriptome. Consistently, we found improved hair …
We then injected a newly developed AAV vector (AAV-PHP.eB) based CasRx into the inner ears of neonatal Bth mice, and we found that Tm …
189 results