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A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia.
Jiang C, Melles RB, Yin J, Fan Q, Guo X, Cheng CY, He M, Mackey DA, Guggenheim JA, Klaver C; Consortium for Refractive Error and Myopia (CREAM); Nair KS, Jorgenson E, Choquet H. Jiang C, et al. Front Genet. 2023 Jun 7;14:1113058. doi: 10.3389/fgene.2023.1113058. eCollection 2023. Front Genet. 2023. PMID: 37351342 Free PMC article.
Methods: Here, we conducted a multiethnic genome-wide association study (GWAS) of AL in 19,420 adults of European, Latino, Asian, and African ancestry from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort, with replication in a subset of the Consortium …
Methods: Here, we conducted a multiethnic genome-wide association study (GWAS) of AL in 19,420 adults of European, Latino, Asian, and Africa …
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, MacGregor S, Hewitt AW, Nag A, Cheng CY, Yonova-Doing E, Zhou X, Ikram MK, Buitendijk GH, McMahon G, Kemp JP, Pourcain BS, Simpson CL, Mäkelä KM, Lehtimäki T, Kähönen M, Paterson AD, Hosseini SM, Wong HS, Xu L, Jonas JB, Pärssinen O, Wedenoja J, Yip SP, Ho DW, Pang CP, Chen LJ, Burdon KP, Craig JE, Klein BE, Klein R, Haller T, Metspalu A, Khor CC, Tai ES, Aung T, Vithana E, Tay WT, Barathi VA; Consortium for Refractive Error and Myopia (CREAM); Chen P, Li R, Liao J, Zheng Y, Ong RT, Döring A; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group; Evans DM, Timpson NJ, Verkerk AJ, Meitinger T, Raitakari O, Hawthorne F, Spector TD, Karssen LC, Pirastu M, Murgia F, Ang W; Wellcome Trust Case Control Consortium 2 (WTCCC2); Mishra A, Montgomery GW, Pennell CE, Cumberland PM, Cotlarciuc I, Mitchell P, Wang JJ, Schache M, Janmahasatian S, Igo RP Jr, Lass JH, Chew E, Iyengar SK; Fuchs' Genetics Multi-Center Study Group; Gorgels TG, Rudan I, Hayward C, Wright AF, Polasek O, Vatavuk Z, Wilson JF, Fleck B, Zeller T, Mirshahi A, Müller C, Uitterlinden AG… See abstract for full author list ➔ Verhoeven VJ, et al. Nat Genet. 2013 Mar;45(3):314-8. doi: 10.1038/ng.2554. Epub 2013 Feb 10. Nat Genet. 2013. PMID: 23396134 Free PMC article.
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. ...We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. ...
Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. ...We identified 16 new loci …
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error.
Musolf AM, Haarman AEG, Luben RN, Ong JS, Patasova K, Trapero RH, Marsh J, Jain I, Jain R, Wang PZ, Lewis DD, Tedja MS, Iglesias AI, Li H, Cowan CS; Consortium for Refractive Error and Myopia (CREAM); Biino G, Klein AP, Duggal P, Mackey DA, Hayward C, Haller T, Metspalu A, Wedenoja J, Pärssinen O, Cheng CY, Saw SM, Stambolian D, Hysi PG, Khawaja AP, Vitart V, Hammond CJ, van Duijn CM, Verhoeven VJM, Klaver CCW, Bailey-Wilson JE. Musolf AM, et al. Commun Biol. 2023 Jan 3;6(1):6. doi: 10.1038/s42003-022-04323-7. Commun Biol. 2023. PMID: 36596879 Free PMC article.
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. ...Identification of genes contributing to refractive error and future understanding of their function may …
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and envi …
APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
Tkatchenko AV, Tkatchenko TV, Guggenheim JA, Verhoeven VJ, Hysi PG, Wojciechowski R, Singh PK, Kumar A, Thinakaran G; Consortium for Refractive Error and Myopia (CREAM); Williams C. Tkatchenko AV, et al. PLoS Genet. 2015 Aug 27;11(8):e1005432. doi: 10.1371/journal.pgen.1005432. eCollection 2015 Aug. PLoS Genet. 2015. PMID: 26313004 Free PMC article.
However, gene variants identified to date explain less than 10% of the variance in refractive error, leaving the majority of heritability unexplained ("missing heritability"). ...Here, we found that low-frequency variants near the 5'-end of APLP2 were associated wit …
However, gene variants identified to date explain less than 10% of the variance in refractive error, leaving the majority of h …
Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia.
Tideman JWL, Pärssinen O, Haarman AEG, Khawaja AP, Wedenoja J, Williams KM, Biino G, Ding X, Kähönen M, Lehtimäki T, Raitakari OT, Cheng CY, Jonas JB, Young TL, Bailey-Wilson JE, Rahi J, Williams C, He M, Mackey DA, Guggenheim JA; UK Biobank Eye and Vision Consortium and the Consortium for Refractive Error and Myopia (CREAM Consortium). Tideman JWL, et al. JAMA Ophthalmol. 2021 Jun 1;139(6):601-609. doi: 10.1001/jamaophthalmol.2021.0497. JAMA Ophthalmol. 2021. PMID: 33830181 Free PMC article.
RESULTS: A total of 51 841 unrelated individuals of European ancestry and 2165 unrelated individuals of Asian ancestry were assigned to a specific refractive error group and included in our analyses. Polygenic risk scores derived from all 4 GWAS analyses were predic …
RESULTS: A total of 51 841 unrelated individuals of European ancestry and 2165 unrelated individuals of Asian ancestry were assigned to a sp …
Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.
Wong YL, Hysi P, Cheung G, Tedja M, Hoang QV, Tompson SWJ, Whisenhunt KN, Verhoeven V, Zhao W, Hess M, Wong CW, Kifley A, Hosoda Y, Haarman AEG, Hopf S, Laspas P, Sensaki S, Sim X, Miyake M, Tsujikawa A, Lamoureux E, Ohno-Matsui K, Nickels S, Mitchell P, Wong TY, Wang JJ, Hammond CJ, Barathi VA, Cheng CY, Yamashiro K, Young TL, Klaver CCW, Saw SM; Consortium of Refractive Error, Myopia (CREAM). Wong YL, et al. PLoS One. 2019 Aug 15;14(8):e0220143. doi: 10.1371/journal.pone.0220143. eCollection 2019. PLoS One. 2019. PMID: 31415580 Free PMC article.
PURPOSE: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). METHOD …
PURPOSE: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individua …
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
Fan Q, Pozarickij A, Tan NYQ, Guo X, Verhoeven VJM, Vitart V, Guggenheim JA, Miyake M, Tideman JWL, Khawaja AP, Zhang L, MacGregor S, Höhn R, Chen P, Biino G, Wedenoja J, Saffari SE, Tedja MS, Xie J, Lanca C, Wang YX, Sahebjada S, Mazur J, Mirshahi A, Martin NG, Yazar S, Pennell CE, Yap M, Haarman AEG, Enthoven CA, Polling J; Consortium for Refractive Error and Myopia (CREAM); UK Biobank Eye and Vision Consortium; Hewitt AW, Jaddoe VWV, van Duijn CM, Hayward C, Polasek O, Tai ES, Yoshikatsu H, Hysi PG, Young TL, Tsujikawa A, Wang JJ, Mitchell P, Pfeiffer N, Pärssinen O, Foster PJ, Fossarello M, Yip SP, Williams C, Hammond CJ, Jonas JB, He M, Mackey DA, Wong TY, Klaver CCW, Saw SM, Baird PN, Cheng CY. Fan Q, et al. Commun Biol. 2020 Mar 19;3(1):133. doi: 10.1038/s42003-020-0802-y. Commun Biol. 2020. PMID: 32193507 Free PMC article.
Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.
Iglesias AI, Ong JS, Khawaja AP, Gharahkhani P, Tedja MS, Verhoeven VJM, Bonnemaijer PWM, Wolfs RCW, Young TL, Jansonius NM, Craig JE, Stambolian D, van Duijn CM, MacGregor S, Klaver CCW; International Glaucoma Genetics Consortium (IGGC) and Consortium for Refractive Error and Myopia (CREAM). Iglesias AI, et al. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3142-3149. doi: 10.1167/iovs.18-26231. Invest Ophthalmol Vis Sci. 2019. PMID: 31323684 Free PMC article.
PRSs were derived from genome-wide association study meta-analyses conducted by the Consortium for Refractive Error and Myopia (CREAM) and 23andMe. In total, 12 PRSs were constructed and tested. ...
PRSs were derived from genome-wide association study meta-analyses conducted by the Consortium for Refractive Error and …
Education influences the role of genetics in myopia.
Verhoeven VJ, Buitendijk GH; Consortium for Refractive Error and Myopia (CREAM); Rivadeneira F, Uitterlinden AG, Vingerling JR, Hofman A, Klaver CC. Verhoeven VJ, et al. Eur J Epidemiol. 2013 Dec;28(12):973-80. doi: 10.1007/s10654-013-9856-1. Epub 2013 Oct 19. Eur J Epidemiol. 2013. PMID: 24142238 Free PMC article.
A genetic risk score was calculated based on 26 myopia-associated single nucleotide polymorphisms recently discovered by the Consortium for Refractive Error and Myopia. Educational level was obtained by questionnaire and categorized into primary, intermediate …
A genetic risk score was calculated based on 26 myopia-associated single nucleotide polymorphisms recently discovered by the Consortium …
Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study.
Cuellar-Partida G, Williams KM, Yazar S, Guggenheim JA, Hewitt AW, Williams C, Wang JJ, Kho PF, Saw SM, Cheng CY, Wong TY, Aung T, Young TL, Tideman JWL, Jonas JB; Consortium for Refractive Error and Myopia (CREAM); Mitchell P, Wojciechowski R, Stambolian D, Hysi P, Hammond CJ, Mackey DA, Lucas RM, MacGregor S. Cuellar-Partida G, et al. Int J Epidemiol. 2017 Dec 1;46(6):1882-1890. doi: 10.1093/ije/dyx068. Int J Epidemiol. 2017. PMID: 28586461 Free PMC article.
METHODS: We performed MR using results from a meta-analysis of refractive error (RE) genome-wide association study (GWAS) that included 37 382 and 8 376 adult participants of European and Asian ancestry, respectively, published by the Consortium for Refrac …
METHODS: We performed MR using results from a meta-analysis of refractive error (RE) genome-wide association study (GWAS) that …
11 results