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Page 1
Showing results for nogo as
Search for Anogo AS instead (1 results)
Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis.
Nheu D, Ellen O, Ye S, Ozturk E, Pagnin M, Kertadjaja S, Theotokis P, Grigoriadis N, McLean C, Petratos S. Nheu D, et al. Cells. 2022 Nov 25;11(23):3768. doi: 10.3390/cells11233768. Cells. 2022. PMID: 36497029 Free PMC article. Review.
Our research has observed that the obstruction of signaling by inhibitory myelin proteins such as myelin-associated inhibitory factor, Nogo-A, with its receptor (NgR), can regulate microglial cell function and activity in pre-clinical animal studies. ...Additionally, the p …
Our research has observed that the obstruction of signaling by inhibitory myelin proteins such as myelin-associated inhibitory factor, No …
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y. Zhang Y, et al. Redox Biol. 2023 Dec;68:102944. doi: 10.1016/j.redox.2023.102944. Epub 2023 Oct 21. Redox Biol. 2023. PMID: 37890359 Free PMC article.
We previously showed endothelial Nogo-B as a key regulator of endothelial function in the setting of hypertension. Here, we aim to further assess the role of Nogo-B in coronary atherosclerosis in ApoE(-/-) mice with pressure overload. ...Nogo-B may hold the p …
We previously showed endothelial Nogo-B as a key regulator of endothelial function in the setting of hypertension. Here, we aim to fu …
Novel Function of Nogo-A as Negative Regulator of Endothelial Progenitor Cell Angiogenic Activity: Impact in Oxygen-Induced Retinopathy.
Ruknudin P, Nazari AR, Wirth M, Lahaie I, Bajon E, Rivard A, Chemtob S, Desjarlais M. Ruknudin P, et al. Int J Mol Sci. 2023 Aug 24;24(17):13185. doi: 10.3390/ijms241713185. Int J Mol Sci. 2023. PMID: 37685993 Free PMC article.
Based on the significant impact of EPCs in retinal vascularization, we surmised that Nogo-A affects EPC function, and proceeded to investigate the role of Nogo-A on EPC function in OIR. ...The findings revealed that hyperoxia-induced EPC malfunction is mediated to a …
Based on the significant impact of EPCs in retinal vascularization, we surmised that Nogo-A affects EPC function, and proceeded to in …
Astrocytes as a target for Nogo-A and implications for synapse formation in vitro and in a model of acute demyelination.
Espírito-Santo S, Coutinho VG, Dezonne RS, Stipursky J, Dos Santos-Rodrigues A, Batista C, Paes-de-Carvalho R, Fuss B, Gomes FCA. Espírito-Santo S, et al. Glia. 2021 Jun;69(6):1429-1443. doi: 10.1002/glia.23971. Epub 2021 Jan 26. Glia. 2021. PMID: 33497496
However, the roles of Nogo-A-astrocyte interactions and their implications in synapse development and plasticity have not been characterized. Therefore, we aimed to investigate whether Nogo-A affects the capacity of astrocytes to induce synaptogenesis. Additionally, …
However, the roles of Nogo-A-astrocyte interactions and their implications in synapse development and plasticity have not been charac …
Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma.
Yu M, Zhang S, Guo F, Yang X, Li Q, Wei Z, Han J, Duan Y, Chen Y. Yu M, et al. Cell Signal. 2020 Jan;65:109429. doi: 10.1016/j.cellsig.2019.109429. Epub 2019 Oct 22. Cell Signal. 2020. PMID: 31654717
Furthermore, we identified a PPARgamma response element (PPRE) in Nogo-B promoter and found PPARgamma enhanced Nogo-B transcription in a PPRE-dependent manner. ...In summary, our study identifies Nogo-B as a new molecular target of PPARgamma, and suggests inc …
Furthermore, we identified a PPARgamma response element (PPRE) in Nogo-B promoter and found PPARgamma enhanced Nogo-B transcri …
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.
Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD. Rodriguez CM, et al. Cell Rep. 2022 Oct 25;41(4):111505. doi: 10.1016/j.celrep.2022.111505. Cell Rep. 2022. PMID: 36288715 Free PMC article.
We provide evidence that ataxin-2 shares a role with the RTN4/NoGo-Receptor in limiting axonal regeneration. Reduction of either protein increases axonal regrowth following axotomy. These data define the RTN4/NoGo-Receptor as a novel therapeutic target for ALS and S …
We provide evidence that ataxin-2 shares a role with the RTN4/NoGo-Receptor in limiting axonal regeneration. Reduction of either prot …
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y. Xue C, et al. Cell Rep. 2024 Sep 24;43(9):114691. doi: 10.1016/j.celrep.2024.114691. Epub 2024 Sep 3. Cell Rep. 2024. PMID: 39235944 Free article.
We discover that Nogo-B interacts with liver X receptor alpha (LXRalpha), and Nogo-B deficiency inhibits ubiquitination degradation of LXRalpha, thereby enhancing its function on cholesterol excretion. Decreased cellular cholesterol levels further activate SREBP2 an …
We discover that Nogo-B interacts with liver X receptor alpha (LXRalpha), and Nogo-B deficiency inhibits ubiquitination degrad …
Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells.
Kawaguchi N, Tashiro K, Taniguchi K, Kawai M, Tanaka K, Okuda J, Hayashi M, Uchiyama K. Kawaguchi N, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2600-2609. doi: 10.1016/j.bbadis.2018.04.018. Epub 2018 Apr 21. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29684585 Free article.
Nogo-B is a member of the Nogo/Reticulon-4 family and has been reported to be an inducer of apoptosis in certain types of cancer cells. However, the role of Nogo-B in human cancer remains less understood. Here, we demonstrated the functions of Nogo-B i …
Nogo-B is a member of the Nogo/Reticulon-4 family and has been reported to be an inducer of apoptosis in certain types of canc …
Nogo-A Antibodies for Progressive Multiple Sclerosis.
Ineichen BV, Plattner PS, Good N, Martin R, Linnebank M, Schwab ME. Ineichen BV, et al. CNS Drugs. 2017 Mar;31(3):187-198. doi: 10.1007/s40263-017-0407-2. CNS Drugs. 2017. PMID: 28105588 Free article. Review.
Nogo-A-suppressing antibodies could be novel drug candidates for the relapsing as well as the progressive MS disease stage. In this review, we summarize the available pre-clinical and clinical evidence on Nogo-A and elucidate the potential of Nogo-A-antibodie …
Nogo-A-suppressing antibodies could be novel drug candidates for the relapsing as well as the progressive MS disease stage. In this r …
Non-canonical actions of Nogo-A and its receptors.
Seiler S, Di Santo S, Widmer HR. Seiler S, et al. Biochem Pharmacol. 2016 Jan 15;100:28-39. doi: 10.1016/j.bcp.2015.08.113. Epub 2015 Sep 4. Biochem Pharmacol. 2016. PMID: 26348872 Review.
Nogo-A is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system. ...Aim of the present commentary is to draw attention on these less well-known and sometimes controversial roles of Nogo-A. Furthermore, we are …
Nogo-A is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system. ...Aim of t …
31,304 results
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