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Increased Medial Temporal Tau Positron Emission Tomography Uptake in the Absence of Amyloid-β Positivity.
Costoya-Sánchez A, Moscoso A, Silva-Rodríguez J, Pontecorvo MJ, Devous MD Sr, Aguiar P, Schöll M, Grothe MJ; Alzheimer’s Disease Neuroimaging Initiative and the Harvard Aging Brain Study. Costoya-Sánchez A, et al. JAMA Neurol. 2023 Oct 1;80(10):1051-1061. doi: 10.1001/jamaneurol.2023.2560. JAMA Neurol. 2023. PMID: 37578787 Free PMC article.
Little is known about the longitudinal course of this condition, and its association with Alzheimer disease (AD) remains unclear. OBJECTIVE: To study the pathologic and clinical course of older individuals with PET-evidenced MTL tau deposition (TMTL+) in the absence …
Little is known about the longitudinal course of this condition, and its association with Alzheimer disease (AD) remains uncle …
Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation.
Farrell ME, Jiang S, Schultz AP, Properzi MJ, Price JC, Becker JA, Jacobs HIL, Hanseeuw BJ, Rentz DM, Villemagne VL, Papp KV, Mormino EC, Betensky RA, Johnson KA, Sperling RA, Buckley RF; Alzheimer's Disease Neuroimaging Initiative and the Harvard Aging Brain Study. Farrell ME, et al. Neurology. 2021 Jan 26;96(4):e619-e631. doi: 10.1212/WNL.0000000000011214. Epub 2020 Nov 16. Neurology. 2021. PMID: 33199430 Free PMC article.
METHODS: Sequential Abeta cutoffs were tested to identify the lowest cutoff associated with future change in cognition (Preclinical Alzheimer Cognitive Composite [PACC]) and Abeta-PET in clinically normal participants from the Harvard Aging Brain Study (n = 342), Australia …
METHODS: Sequential Abeta cutoffs were tested to identify the lowest cutoff associated with future change in cognition (Preclinical Alzhe …
Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease.
Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC, Schultz A, Sperling RA, Greicius MD, Cobos I, Poston KL, Mormino EC; Alzheimer’s Disease Neuroimaging Initiative and the Harvard Aging Brain Study. Young CB, et al. JAMA Neurol. 2022 Jun 1;79(6):592-603. doi: 10.1001/jamaneurol.2022.0676. JAMA Neurol. 2022. PMID: 35435938 Free PMC article.
IMPORTANCE: Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select individuals at risk for AD and halt the progression of disease. ...Follow-up analyses used observa …
IMPORTANCE: Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for pr …