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Page 1
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer.
McLane LM, Abdel-Hakeem MS, Wherry EJ. McLane LM, et al. Among authors: abdel hakeem ms. Annu Rev Immunol. 2019 Apr 26;37:457-495. doi: 10.1146/annurev-immunol-041015-055318. Epub 2019 Jan 24. Annu Rev Immunol. 2019. PMID: 30676822 Review.
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Beltra JC, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ. Beltra JC, et al. Among authors: abdel hakeem ms. Immunity. 2020 May 19;52(5):825-841.e8. doi: 10.1016/j.immuni.2020.04.014. Epub 2020 May 11. Immunity. 2020. PMID: 32396847 Free PMC article.
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics.
Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, Karakousis GC, Xu X, Mitchell TC, Huang AC, Wherry EJ. Giles JR, et al. Among authors: abdel hakeem ms. Nat Immunol. 2022 Nov;23(11):1600-1613. doi: 10.1038/s41590-022-01338-4. Epub 2022 Oct 21. Nat Immunol. 2022. PMID: 36271148 Free PMC article.
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure.
Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, Klapholz M, Decaluwe H, Huang AC, Berger SL, Garcia KC, Wherry EJ. Beltra JC, et al. Among authors: abdel hakeem ms. Immunity. 2023 Dec 12;56(12):2699-2718.e11. doi: 10.1016/j.immuni.2023.11.005. Immunity. 2023. PMID: 38091951 Free PMC article.
Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis.
Faliti CE, Mesina M, Choi J, Bélanger S, Marshall MA, Tipton CM, Hicks S, Chappa P, Cardenas MA, Abdel-Hakeem M, Thinnes TC, Cottrell C, Scharer CD, Schief WR, Nemazee D, Woodruff MC, Lindner JM, Sanz I, Crotty S. Faliti CE, et al. Among authors: abdel hakeem m. Immunity. 2024 Dec 10;57(12):2772-2789.e8. doi: 10.1016/j.immuni.2024.11.006. Epub 2024 Nov 28. Immunity. 2024. PMID: 39612915
Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection.
Eisa M, Gomez-Escobar E, Bédard N, Abdeltawab NF, Flores N, Mazouz S, Fieffé-Bédard A, Sakayan P, Gridley J, Abdel-Hakeem MS, Bruneau J, Grakoui A, Shoukry NH. Eisa M, et al. Among authors: abdel hakeem ms. Front Immunol. 2024 Jun 10;15:1403769. doi: 10.3389/fimmu.2024.1403769. eCollection 2024. Front Immunol. 2024. PMID: 38947319 Free PMC article.
Nanocarriers: A Reliable Tool for the Delivery of Anticancer Drugs.
Sabit H, Abdel-Hakeem M, Shoala T, Abdel-Ghany S, Abdel-Latif MM, Almulhim J, Mansy M. Sabit H, et al. Among authors: abdel hakeem m. Pharmaceutics. 2022 Jul 28;14(8):1566. doi: 10.3390/pharmaceutics14081566. Pharmaceutics. 2022. PMID: 36015192 Free PMC article. Review.
49 results