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Mepolizumab for urban children with exacerbation-prone eosinophilic asthma in the USA (MUPPITS-2): a randomised, double-blind, placebo-controlled, parallel-group trial.
Jackson DJ, Bacharier LB, Gergen PJ, Gagalis L, Calatroni A, Wellford S, Gill MA, Stokes J, Liu AH, Gruchalla RS, Cohen RT, Makhija M, Khurana Hershey GK, O'Connor GT, Pongracic JA, Sherenian MG, Rivera-Spoljaric K, Zoratti EM, Teach SJ, Kattan M, Dutmer CM, Kim H, Lamm C, Sheehan WJ, Segnitz RM, Dill-McFarland KA, Visness CM, Becker PM, Gern JE, Sorkness CA, Busse WW, Altman MC; US National Institute of Allergy and Infectious Disease's Inner City Asthma Consortium. Jackson DJ, et al. Lancet. 2022 Aug 13;400(10351):502-511. doi: 10.1016/S0140-6736(22)01198-9. Lancet. 2022. PMID: 35964610 Free PMC article. Clinical Trial.
Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium.
Zanobetti A, Ryan PH, Coull BA, Luttmann-Gibson H, Datta S, Blossom J, Brokamp C, Lothrop N, Miller RL, Beamer PI, Visness CM, Andrews H, Bacharier LB, Hartert T, Johnson CC, Ownby DR, Khurana Hershey GK, Joseph CLM, Mendonça EA, Jackson DJ, Zoratti EM, Wright AL, Martinez FD, Seroogy CM, Ramratnam SK, Calatroni A, Gern JE, Gold DR; ECHO Children’s Respiratory and Environmental Workgroup. Zanobetti A, et al. JAMA Netw Open. 2024 Feb 5;7(2):e240535. doi: 10.1001/jamanetworkopen.2024.0535. JAMA Netw Open. 2024. PMID: 38416497 Free PMC article.
Associations between outdoor air pollutants and non-viral asthma exacerbations and airway inflammatory responses in children and adolescents living in urban areas in the USA: a retrospective secondary analysis.
Altman MC, Kattan M, O'Connor GT, Murphy RC, Whalen E, LeBeau P, Calatroni A, Gill MA, Gruchalla RS, Liu AH, Lovinsky-Desir S, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Teach SJ, Bacharier LB, Wheatley LM, Sigelman SM, Gergen PJ, Togias A, Busse WW, Gern JE, Jackson DJ; National Institute of Allergy and Infectious Disease's Inner City Asthma Consortium. Altman MC, et al. Lancet Planet Health. 2023 Jan;7(1):e33-e44. doi: 10.1016/S2542-5196(22)00302-3. Lancet Planet Health. 2023. PMID: 36608946 Free PMC article.
Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children.
McCauley KE, Durack J, Lynch KV, Fadrosh DW, Fujimura KE, Vundla F, Özçam M, LeBeau P, Caltroni A, Burns P, Tran HT, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Togias A, Boushey HA, Jackson DJ, Gern JE, Lynch SV; National Institute of Allergy and Infectious Diseases–sponsored Childhood Asthma in Urban Settings Consortium. McCauley KE, et al. J Allergy Clin Immunol. 2024 Jun;153(6):1563-1573. doi: 10.1016/j.jaci.2023.12.032. Epub 2024 Feb 27. J Allergy Clin Immunol. 2024. PMID: 38423369
Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Clay S, Alladina J, Smith NP, Visness CM, Wood RA, O'Connor GT, Cohen RT, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Rivera-Spoljaric K, Robison RG, Gergen PJ, Busse WW, Villani AC, Cho JL, Medoff BD, Gern JE, Jackson DJ, Ober C, Dapas M. Clay S, et al. J Allergy Clin Immunol. 2024 Mar;153(3):809-820. doi: 10.1016/j.jaci.2023.10.023. Epub 2023 Nov 7. J Allergy Clin Immunol. 2024. PMID: 37944567 Free PMC article.
Evaluation of pediatric epigenetic clocks across multiple tissues.
Fang F, Zhou L, Perng W, Marsit CJ, Knight AK, Cardenas A, Aung MT, Hivert MF, Aris IM, Goodrich JM, Smith AK, Gaylord A, Fry RC, Oken E, O'Connor G, Ruden DM, Trasande L, Herbstman JB, Camargo CA Jr, Bush NR, Dunlop AL, Dabelea DM, Karagas MR, Breton CV, Ober C, Everson TM, Page GP, Ladd-Acosta C; program collaborators for Environmental influences on Child Health Outcomes. Fang F, et al. Clin Epigenetics. 2023 Sep 2;15(1):142. doi: 10.1186/s13148-023-01552-3. Clin Epigenetics. 2023. PMID: 37660147 Free PMC article.
A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Morin A, Thompson EE, Helling BA, Shorey-Kendrick LE, Faber P, Gebretsadik T, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Barnes KC, Mathias RA, Altman MC, Hansen K, McEvoy CT, Spindel ER, Hartert T, Jackson DJ, Gern JE, McKennan CG, Ober C; program collaborators for Environmental Influences on Child Health Outcomes and Children’s Respiratory and Environmental Workgroup. Morin A, et al. J Allergy Clin Immunol. 2023 Jun;151(6):1609-1621. doi: 10.1016/j.jaci.2022.12.828. Epub 2023 Feb 6. J Allergy Clin Immunol. 2023. PMID: 36754293 Free PMC article.
19 results