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GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. Gupta V, et al. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. Proc Natl Acad Sci U S A. 2016. PMID: 27621449 Free PMC article.