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Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells.
Singh AK, Wang R, Lombardo KA, Praharaj M, Bullen CK, Um P, Gupta M, Srikrishna G, Davis S, Komm O, Illei PB, Ordonez AA, Bahr M, Huang J, Gupta A, Psoter KJ, Creisher PS, Li M, Pekosz A, Klein SL, Jain SK, Bivalacqua TJ, Yegnasubramanian S, Bishai WR. Singh AK, et al. iScience. 2023 Aug 24;26(10):107733. doi: 10.1016/j.isci.2023.107733. eCollection 2023 Oct 20. iScience. 2023. PMID: 37674985 Free PMC article.
Application of machine learning models to identify serological predictors of COVID-19 severity and outcomes.
Klein S, Dhakal S, Yin A, Escarra-Senmarti M, Demko Z, Pisanic N, Johnston T, Trejo-Zambrano M, Kruczynski K, Lee J, Hardick J, Shea P, Shapiro J, Park HS, Parish M, Caputo C, Ganesan A, Mullapudi S, Gould S, Betenbaugh M, Pekosz A, Heaney CD, Antar A, Manabe Y, Cox A, Karaba A, Andrade F, Zeger S. Klein S, et al. Res Sq [Preprint]. 2023 Nov 13:rs.3.rs-3463155. doi: 10.21203/rs.3.rs-3463155/v1. Res Sq. 2023. Update in: Commun Med (Lond). 2024 Nov 26;4(1):249. doi: 10.1038/s43856-024-00658-w PMID: 38014049 Free PMC article. Updated. Preprint.
Three doses of COVID-19 mRNA vaccine induce class-switched antibody responses in inflammatory arthritis patients on immunomodulatory therapies.
Lee JM, Figueroa A, Sachithanandham J, Li M, Connolly CM, Shapiro JR, Chen Y, Jones M, Dhara VG, Towns M, Lee JS, Peralta SR, Milstone AM, Betenbaugh M, Debes AK, Blankson J, Sitaras I, Yoon S, Thompson EA, Bingham CO 3rd, Klein SL, Pekosz A, Bailey JR. Lee JM, et al. Front Immunol. 2023 Oct 24;14:1266370. doi: 10.3389/fimmu.2023.1266370. eCollection 2023. Front Immunol. 2023. PMID: 38022602 Free PMC article.
Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses.
Dykema AG, Zhang B, Woldemeskel BA, Garliss CC, Cheung LS, Choudhury D, Zhang J, Aparicio L, Bom S, Rashid R, Caushi JX, Hsiue EH, Cascino K, Thompson EA, Kwaa AK, Singh D, Thapa S, Ordonez AA, Pekosz A, D'Alessio FR, Powell JD, Yegnasubramanian S, Zhou S, Pardoll DM, Ji H, Cox AL, Blankson JN, Smith KN. Dykema AG, et al. J Clin Invest. 2021 May 17;131(10):e146922. doi: 10.1172/JCI146922. J Clin Invest. 2021. PMID: 33830946 Free PMC article.
A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants.
Jiang L, Driedonks TAP, Jong WSP, Dhakal S, Bart van den Berg van Saparoea H, Sitaras I, Zhou R, Caputo C, Littlefield K, Lowman M, Chen M, Lima G, Gololobova O, Smith B, Mahairaki V, Riley Richardson M, Mulka KR, Lane AP, Klein SL, Pekosz A, Brayton C, Mankowski JL, Luirink J, Villano JS, Witwer KW. Jiang L, et al. J Extracell Vesicles. 2022 Mar;11(3):e12192. doi: 10.1002/jev2.12192. J Extracell Vesicles. 2022. PMID: 35289114 Free PMC article.
Anti-PF4 antibodies associated with disease severity in COVID-19.
Liu Q, Miao H, Li S, Zhang P, Gerber GF, Follmann D, Ji H, Zeger SL, Chertow DS, Quinn TC, Robinson ML, Kickler TS, Rothman RE, Fenstermacher KZJ, Braunstein EM, Cox AL, Farci P, Fauci AS, Lusso P. Liu Q, et al. Proc Natl Acad Sci U S A. 2022 Nov 22;119(47):e2213361119. doi: 10.1073/pnas.2213361119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322776 Free PMC article.
Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters.
Mulka KR, Beck SE, Solis CV, Johanson AL, Queen SE, McCarron ME, Richardson MR, Zhou R, Marinho P, Jedlicka A, Guerrero-Martin S, Shirk EN, Braxton AM, Brockhurst J, Creisher PS, Dhakal S, Brayton CF, Veenhuis RT, Metcalf Pate KA, Karakousis PC, Zahnow CA, Klein SL, Jain SK, Tarwater PM, Pekosz AS, Villano JS, Mankowski JL; Johns Hopkins COVID-19 Hamster Study Group. Mulka KR, et al. Am J Pathol. 2022 Feb;192(2):195-207. doi: 10.1016/j.ajpath.2021.10.009. Epub 2021 Nov 10. Am J Pathol. 2022. PMID: 34767812 Free PMC article.
43 results