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Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis.
Lopatto EDB, Pinkner JS, Sanick DA, Potter RF, Liu LX, Bazán Villicaña J, Tamadonfar KO, Ye Y, Zimmerman MI, Gualberto NC, Dodson KW, Janetka JW, Hunstad DA, Hultgren SJ. Lopatto EDB, et al. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2409655121. doi: 10.1073/pnas.2409655121. Epub 2024 Sep 17. Proc Natl Acad Sci U S A. 2024. PMID: 39288182 Free PMC article.
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ. Nye TM, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210912119. doi: 10.1073/pnas.2210912119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252016 Free PMC article.
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
Lopatto EDB, Santiago-Borges JM, Sanick DA, Malladi SK, Azimzadeh PN, Timm MW, Fox IF, Schmitz AJ, Turner JS, Ahmed SS, Ortinau L, Gualberto NC, Pinkner JS, Dodson KW, Ellebedy AH, Kau AL, Hultgren SJ. Lopatto EDB, et al. bioRxiv [Preprint]. 2024 Dec 11:2024.12.10.627638. doi: 10.1101/2024.12.10.627638. bioRxiv. 2024. PMID: 39713358 Free PMC article. Preprint.
17 results