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2020 1
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Page 1
Advances in CRISPR therapeutics.
Chavez M, Chen X, Finn PB, Qi LS. Chavez M, et al. Nat Rev Nephrol. 2023 Jan;19(1):9-22. doi: 10.1038/s41581-022-00636-2. Epub 2022 Oct 24. Nat Rev Nephrol. 2023. PMID: 36280707 Free PMC article. Review.
High-content CRISPR screening.
Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, Qi LS, Shapiro RS, Shendure J, Weissman JS, Zhuang X. Bock C, et al. Nat Rev Methods Primers. 2022;2(1):9. doi: 10.1038/s43586-022-00098-7. Epub 2022 Feb 10. Nat Rev Methods Primers. 2022. PMID: 37214176 Free PMC article.
Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome.
Malachowski T, Chandradoss KR, Boya R, Zhou L, Cook AL, Su C, Pham K, Haws SA, Kim JH, Ryu HS, Ge C, Luppino JM, Nguyen SC, Titus KR, Gong W, Wallace O, Joyce EF, Wu H, Rojas LA, Phillips-Cremins JE. Malachowski T, et al. Cell. 2023 Dec 21;186(26):5840-5858.e36. doi: 10.1016/j.cell.2023.11.019. Cell. 2023. PMID: 38134876 Free PMC article.
Multiplexed genome regulation in vivo with hyper-efficient Cas12a.
Guo LY, Bian J, Davis AE, Liu P, Kempton HR, Zhang X, Chemparathy A, Gu B, Lin X, Rane DA, Xu X, Jamiolkowski RM, Hu Y, Wang S, Qi LS. Guo LY, et al. Nat Cell Biol. 2022 Apr;24(4):590-600. doi: 10.1038/s41556-022-00870-7. Epub 2022 Apr 12. Nat Cell Biol. 2022. PMID: 35414015 Free PMC article.
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.
Dekker J, Alber F, Aufmkolk S, Beliveau BJ, Bruneau BG, Belmont AS, Bintu L, Boettiger A, Calandrelli R, Disteche CM, Gilbert DM, Gregor T, Hansen AS, Huang B, Huangfu D, Kalhor R, Leslie CS, Li W, Li Y, Ma J, Noble WS, Park PJ, Phillips-Cremins JE, Pollard KS, Rafelski SM, Ren B, Ruan Y, Shav-Tal Y, Shen Y, Shendure J, Shu X, Strambio-De-Castillia C, Vertii A, Zhang H, Zhong S. Dekker J, et al. Mol Cell. 2023 Aug 3;83(15):2624-2640. doi: 10.1016/j.molcel.2023.06.018. Epub 2023 Jul 6. Mol Cell. 2023. PMID: 37419111 Free PMC article. Review.
Engineering 3D genome organization.
Wang H, Han M, Qi LS. Wang H, et al. Nat Rev Genet. 2021 Jun;22(6):343-360. doi: 10.1038/s41576-020-00325-5. Epub 2021 Feb 8. Nat Rev Genet. 2021. PMID: 33558716 Review.
High-throughput Oligopaint screen identifies druggable 3D genome regulators.
Park DS, Nguyen SC, Isenhart R, Shah PP, Kim W, Barnett RJ, Chandra A, Luppino JM, Harke J, Wai M, Walsh PJ, Abdill RJ, Yang R, Lan Y, Yoon S, Yunker R, Kanemaki MT, Vahedi G, Phillips-Cremins JE, Jain R, Joyce EF. Park DS, et al. Nature. 2023 Aug;620(7972):209-217. doi: 10.1038/s41586-023-06340-w. Epub 2023 Jul 12. Nature. 2023. PMID: 37438531 Free PMC article.
CRISPR technologies for precise epigenome editing.
Nakamura M, Gao Y, Dominguez AA, Qi LS. Nakamura M, et al. Nat Cell Biol. 2021 Jan;23(1):11-22. doi: 10.1038/s41556-020-00620-7. Epub 2021 Jan 8. Nat Cell Biol. 2021. PMID: 33420494 Review.
Genome folding principles revealed in condensin-depleted mitotic chromosomes.
Zhao H, Lin Y, Lin E, Liu F, Shu L, Jing D, Wang B, Wang M, Shan F, Zhang L, Lam JC, Midla SC, Giardine BM, Keller CA, Hardison RC, Blobel GA, Zhang H. Zhao H, et al. bioRxiv [Preprint]. 2023 Nov 13:2023.11.09.566494. doi: 10.1101/2023.11.09.566494. bioRxiv. 2023. Update in: Nat Genet. 2024 Jun;56(6):1213-1224. doi: 10.1038/s41588-024-01759-x PMID: 38014261 Free PMC article. Updated. Preprint.
48 results