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Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion.
McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP, Friedl A, Kolesar J, Marnocha R, Volkman J, Zhang J, Hammershaimb L, Zwiebel JA, Wilding G. McNeel DG, et al. Clin Cancer Res. 2005 Nov 1;11(21):7851-60. doi: 10.1158/1078-0432.CCR-05-0262. Clin Cancer Res. 2005. PMID: 16278408 Clinical Trial.
Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers.
Ramanathan RK, Fakih M, Mani S, Deutsch M, Perez RP, Ritter MA, Eiseman JL, Ivy SP, Trump DL, Belani CP, Parise RA, Potter DM, Egorin MJ. Ramanathan RK, et al. Cancer Chemother Pharmacol. 2006 Apr;57(4):465-74. doi: 10.1007/s00280-005-0071-y. Epub 2005 Aug 25. Cancer Chemother Pharmacol. 2006. PMID: 16133531 Clinical Trial.