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A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling.
Köhler A, Demir U, Kickstein E, Krauss S, Aigner J, Aranda-Orgillés B, Karagiannidis AI, Achmüller C, Bu H, Wunderlich A, Schweiger MR, Schaefer G, Schweiger S, Klocker H, Schneider R. Köhler A, et al. Mol Cancer. 2014 Jun 9;13:146. doi: 10.1186/1476-4598-13-146. Mol Cancer. 2014. PMID: 24913494 Free PMC article.
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Aranda-Orgillés B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S. Aranda-Orgillés B, et al. J Biol Chem. 2011 Nov 18;286(46):39945-57. doi: 10.1074/jbc.M111.224451. Epub 2011 Sep 19. J Biol Chem. 2011. PMID: 21930711 Free PMC article.