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Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Sims EK, Kulkarni A, Hull A, Woerner SE, Cabrera S, Mastrandrea LD, Hammoud B, Sarkar S, Nakayasu ES, Mastracci TL, Perkins SM, Ouyang F, Webb-Robertson BJ, Enriquez JR, Tersey SA, Evans-Molina C, Long SA, Blanchfield L, Gerner EW, Mirmira RG, DiMeglio LA. Sims EK, et al. Cell Rep Med. 2023 Nov 21;4(11):101261. doi: 10.1016/j.xcrm.2023.101261. Epub 2023 Nov 1. Cell Rep Med. 2023. PMID: 37918404 Free PMC article. Clinical Trial.
A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice.
Cao S, Budina E, Raczy MM, Solanki A, Nguyen M, Beckman TN, Reda JW, Hultgren K, Ang PS, Slezak AJ, Hesser LA, Alpar AT, Refvik KC, Shores LS, Pillai I, Wallace RP, Dhar A, Watkins EA, Hubbell JA. Cao S, et al. Nat Biomed Eng. 2024 May;8(5):611-627. doi: 10.1038/s41551-024-01190-x. Epub 2024 Apr 1. Nat Biomed Eng. 2024. PMID: 38561491 Free PMC article.
Cell-targeted vaccines: implications for adaptive immunity.
Ung T, Rutledge NS, Weiss AM, Esser-Kahn AP, Deak P. Ung T, et al. Front Immunol. 2023 Aug 16;14:1221008. doi: 10.3389/fimmu.2023.1221008. eCollection 2023. Front Immunol. 2023. PMID: 37662903 Free PMC article. Review.
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice.
Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG. Muralidharan C, et al. J Clin Invest. 2024 Jun 18;134(16):e176136. doi: 10.1172/JCI176136. J Clin Invest. 2024. PMID: 38889047 Free PMC article.
15 results