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Page 1
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.
Casillo SM, Gatesman TA, Chilukuri A, Varadharajan S, Johnson BJ, David Premkumar DR, Jane EP, Plute TJ, Koncar RF, Stanton AJ, Biagi-Junior CAO, Barber CS, Halbert ME, Golbourn BJ, Halligan K, Cruz AF, Mansi NM, Cheney A, Mullett SJ, Land CV, Perez JL, Myers MI, Agrawal N, Michel JJ, Chang YF, Vaske OM, MichaelRaj A, Lieberman FS, Felker J, Shiva S, Bertrand KC, Amankulor N, Hadjipanayis CG, Abdullah KG, Zinn PO, Friedlander RM, Abel TJ, Nazarian J, Venneti S, Filbin MG, Gelhaus SL, Mack SC, Pollack IF, Agnihotri S. Casillo SM, et al. Cell Rep. 2024 Jan 23;43(1):113557. doi: 10.1016/j.celrep.2023.113557. Epub 2023 Dec 18. Cell Rep. 2024. PMID: 38113141 Free article.
Dietary dicarboxylic acids provide a non-storable alternative fat source that protects mice against obesity.
Goetzman ES, Zhang BB, Zhang Y, Bharathi SS, Bons J, Rose J, Shah S, Solo KJ, Schmidt AV, Richert AC, Mullett SJ, Gelhaus SL, Rao KS, Shiva SS, Pfister KE, Silva Barbosa A, Sims-Lucas S, Dobrowolski SF, Schilling B. Goetzman ES, et al. J Clin Invest. 2024 Apr 30;134(12):e174186. doi: 10.1172/JCI174186. Online ahead of print. J Clin Invest. 2024. PMID: 38687608 Free PMC article.
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.
McIlvried LA, Martel Matos AA, Yuan MM, Atherton MA, Obuekwe F, Nilsen ML, Nikpoor AR, Talbot S, Bruno TC, Taggart DN, Johnson LK, Ferris RL, P Zandberg D, Scheff NN. McIlvried LA, et al. J Immunother Cancer. 2024 Nov 17;12(11):e009962. doi: 10.1136/jitc-2024-009962. J Immunother Cancer. 2024. PMID: 39551606 Free PMC article.
Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.
Jane EP, Reslink MC, Gatesman TA, Halbert ME, Miller TA, Golbourn BJ, Casillo SM, Mullett SJ, Wendell SG, Obodo U, Mohanakrishnan D, Dange R, Michealraj A, Brenner C, Agnihotri S, Premkumar DR, Pollack IF. Jane EP, et al. Mol Oncol. 2023 Sep;17(9):1821-1843. doi: 10.1002/1878-0261.13427. Epub 2023 May 12. Mol Oncol. 2023. PMID: 37014128 Free PMC article.
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Tangudu NK, et al. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. Cancer Res Commun. 2024. PMID: 38626341 Free PMC article.
A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study.
Seymour CW, Urbanek KL, Nakayama A, Kennedy JN, Powell R, Robinson RAS, Kapp KL, Billiar TR, Vodovotz Y, Gelhaus SL, Cooper VS, Tang L, Mayr F, Reitz KM, Horvat C, Meyer NJ, Dickson RP, Angus D, Palmer OP. Seymour CW, et al. Crit Care Explor. 2023 Oct 27;5(11):e0974. doi: 10.1097/CCE.0000000000000974. eCollection 2023 Nov. Crit Care Explor. 2023. PMID: 38304708 Free PMC article.
ATR promotes mTORC1 activity via de novo cholesterol synthesis.
Tangudu NK, Grumet AN, Fang R, Buj R, Cole AR, Uboveja A, Amalric A, Yang B, Huang Z, Happe C, Sun M, Gelhaus SL, MacDonald ML, Hempel N, Snyder NW, Kedziora KM, Valvezan AJ, Aird KM. Tangudu NK, et al. bioRxiv [Preprint]. 2024 Oct 24:2023.10.27.564195. doi: 10.1101/2023.10.27.564195. bioRxiv. 2024. PMID: 37961201 Free PMC article. Preprint.
Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling.
Koudelka A, Buchan GJ, Cechova V, O'Brien JP, Liu H, Woodcock SR, Mullett SJ, Zhang C, Freeman BA, Gelhaus SL. Koudelka A, et al. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579101. doi: 10.1101/2024.02.06.579101. bioRxiv. 2024. Update in: J Lipid Res. 2024 Nov 19;66(1):100705. doi: 10.1016/j.jlr.2024.100705 PMID: 38370667 Free PMC article. Updated. Preprint.
11 results