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Increased glucose availability sensitizes pancreatic cancer to chemotherapy.
Vaziri-Gohar A, Hue JJ, Abbas A, Graor HJ, Hajihassani O, Zarei M, Titomihelakis G, Feczko J, Rathore M, Chelstowska S, Loftus AW, Wang R, Zarei M, Goudarzi M, Zhang R, Willard B, Zhang L, Kresak A, Willis JE, Wang GM, Tatsuoka C, Salvino JM, Bederman I, Brunengraber H, Lyssiotis CA, Brody JR, Winter JM. Vaziri-Gohar A, et al. Nat Commun. 2023 Jun 28;14(1):3823. doi: 10.1038/s41467-023-38921-8. Nat Commun. 2023. PMID: 37380658 Free PMC article.
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T. Ferretti GDS, et al. Cell Death Differ. 2024 Jul;31(7):881-896. doi: 10.1038/s41418-024-01310-9. Epub 2024 May 28. Cell Death Differ. 2024. PMID: 38802657 Free PMC article.
Molecular glues that inhibit deubiquitylase activity and inflammatory signalling.
Chandler F, Reddy PAN, Bhutda S, Ross RL, Datta A, Walden M, Walker K, Di Donato S, Cassel JA, Prakesch MA, Aman A, Datti A, Campbell LJ, Foglizzo M, Bell L, Stein DN, Ault JR, Al-Awar RS, Calabrese AN, Sicheri F, Del Galdo F, Salvino JM, Greenberg RA, Zeqiraj E. Chandler F, et al. bioRxiv [Preprint]. 2024 Nov 15:2024.09.07.611787. doi: 10.1101/2024.09.07.611787. bioRxiv. 2024. PMID: 39282282 Free PMC article. Preprint.
Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.
Vaziri-Gohar A, Cassel J, Mohammed FS, Zarei M, Hue JJ, Hajihassani O, Graor HJ, Srikanth YVV, Karim SA, Abbas A, Prendergast E, Chen V, Katayama ES, Dukleska K, Khokhar I, Andren A, Zhang L, Wu C, Erokwu B, Flask CA, Zarei M, Wang R, Rothermel LD, Romani AMP, Bowers J, Getts R, Tatsuoka C, Morton JP, Bederman I, Brunengraber H, Lyssiotis CA, Salvino JM, Brody JR, Winter JM. Vaziri-Gohar A, et al. Nat Cancer. 2022 Jul;3(7):852-865. doi: 10.1038/s43018-022-00393-y. Epub 2022 Jun 9. Nat Cancer. 2022. PMID: 35681100 Free PMC article.
14 results