RF1 AG056114/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2017	2
2018	7
2019	3
2020	3
2024	0

1

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H. Zhao Y, et al. Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031. Neuron. 2018. PMID: 29518356 Free PMC article.

2

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF. Zhong L, et al. Nat Commun. 2019 Mar 25;10(1):1365. doi: 10.1038/s41467-019-09118-9. Nat Commun. 2019. PMID: 30911003 Free PMC article.

3

Molecular insights into cortico-striatal miscommunications in Huntington's disease.

Veldman MB, Yang XW. Veldman MB, et al. Curr Opin Neurobiol. 2018 Feb;48:79-89. doi: 10.1016/j.conb.2017.10.019. Epub 2017 Nov 7. Curr Opin Neurobiol. 2018. PMID: 29125980 Free PMC article. Review.

4

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H. Jiang LL, et al. J Clin Invest. 2019 May 21;129(8):3103-3120. doi: 10.1172/JCI127695. J Clin Invest. 2019. PMID: 31112137 Free PMC article.

5

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington's disease patients.

Lee CYD, Wang N, Shen K, Stricos M, Langfelder P, Cheon KH, Cortés EP, Vinters HV, Vonsattel JP, Wexler NS, Damoiseaux R, Frydman J, Yang XW. Lee CYD, et al. Sci Rep. 2020 Nov 20;10(1):20295. doi: 10.1038/s41598-020-77164-1. Sci Rep. 2020. PMID: 33219289 Free PMC article.

6

Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.

Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Liu T, et al. J Exp Med. 2020 Dec 7;217(12):e20200474. doi: 10.1084/jem.20200474. J Exp Med. 2020. PMID: 32941599 Free PMC article.

7

Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes.

Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H. Du Y, et al. J Exp Med. 2018 Jun 4;215(6):1665-1677. doi: 10.1084/jem.20171193. Epub 2018 May 8. J Exp Med. 2018. PMID: 29739836 Free PMC article.

8

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression.

Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, Bu G, Huang TY, Xu H, Zhang J. Zhuang K, et al. Cell Rep. 2018 Jul 17;24(3):701-712. doi: 10.1016/j.celrep.2018.06.055. Cell Rep. 2018. PMID: 30021166 Free PMC article.

9

Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.

Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, Kiss G, Keresztessy Z, Vámosi G, Hickman J, Xu H, Dormann D, Hortobagyi T, Antal M, Nógrádi A, Nagy L. Simandi Z, et al. J Neurosci. 2018 Aug 29;38(35):7683-7700. doi: 10.1523/JNEUROSCI.3389-17.2018. Epub 2018 Jul 27. J Neurosci. 2018. PMID: 30054395 Free PMC article.

10

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.

Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW. Lee CYD, et al. Neuron. 2018 Mar 7;97(5):1032-1048.e5. doi: 10.1016/j.neuron.2018.02.002. Neuron. 2018. PMID: 29518357 Free PMC article.

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