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Deletion at fragile sites is a common and early event in Barrett's esophagus.
Lai LA, Kostadinov R, Barrett MT, Peiffer DA, Pokholok D, Odze R, Sanchez CA, Maley CC, Reid BJ, Gunderson KL, Rabinovitch PS. Lai LA, et al. Mol Cancer Res. 2010 Aug;8(8):1084-94. doi: 10.1158/1541-7786.MCR-09-0529. Epub 2010 Jul 20. Mol Cancer Res. 2010. PMID: 20647332 Free PMC article.