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Solute probes of conformational changes in open complex (RPo) formation by Escherichia coli RNA polymerase at the lambdaPR promoter: evidence for unmasking of the active site in the isomerization step and for large-scale coupled folding in the subsequent conversion to RPo.
Kontur WS, Saecker RM, Davis CA, Capp MW, Record MT Jr. Kontur WS, et al. Biochemistry. 2006 Feb 21;45(7):2161-77. doi: 10.1021/bi051835v. Biochemistry. 2006. PMID: 16475805 Free PMC article.