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De novo protein design, a retrospective.
Korendovych IV, DeGrado WF. Korendovych IV, et al. Q Rev Biophys. 2020 Feb 11;53:e3. doi: 10.1017/S0033583519000131. Q Rev Biophys. 2020. PMID: 32041676 Free PMC article. Review.
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S. Pahuja KB, et al. Cancer Cell. 2018 Nov 12;34(5):792-806.e5. doi: 10.1016/j.ccell.2018.09.010. Epub 2018 Oct 25. Cancer Cell. 2018. PMID: 30449325 Free PMC article.
SNAC-tag for sequence-specific chemical protein cleavage.
Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF. Dang B, et al. Nat Methods. 2019 Apr;16(4):319-322. doi: 10.1038/s41592-019-0357-3. Epub 2019 Mar 25. Nat Methods. 2019. PMID: 30923372 Free PMC article.
Constructing ion channels from water-soluble α-helical barrels.
Scott AJ, Niitsu A, Kratochvil HT, Lang EJM, Sengel JT, Dawson WM, Mahendran KR, Mravic M, Thomson AR, Brady RL, Liu L, Mulholland AJ, Bayley H, DeGrado WF, Wallace MI, Woolfson DN. Scott AJ, et al. Nat Chem. 2021 Jul;13(7):643-650. doi: 10.1038/s41557-021-00688-0. Epub 2021 May 10. Nat Chem. 2021. PMID: 33972753 Free PMC article.
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. Zhang SQ, et al. Nat Chem Biol. 2018 Sep;14(9):870-875. doi: 10.1038/s41589-018-0105-5. Epub 2018 Jul 30. Nat Chem Biol. 2018. PMID: 30061717 Free PMC article.
58 results