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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.
Protein kinase C: perfectly balanced.
Newton AC. Newton AC. Crit Rev Biochem Mol Biol. 2018 Apr;53(2):208-230. doi: 10.1080/10409238.2018.1442408. Crit Rev Biochem Mol Biol. 2018. PMID: 29513138 Free PMC article. Review.
Pharmacology on Target.
Kawashima AT, Newton AC. Kawashima AT, et al. Trends Pharmacol Sci. 2020 Apr;41(4):227-230. doi: 10.1016/j.tips.2020.02.002. Epub 2020 Feb 28. Trends Pharmacol Sci. 2020. PMID: 32122673 Free PMC article.
Protein kinase C: release from quarantine by mTORC2.
Baffi TR, Newton AC. Baffi TR, et al. Trends Biochem Sci. 2022 Jun;47(6):518-530. doi: 10.1016/j.tibs.2022.03.003. Epub 2022 Mar 28. Trends Biochem Sci. 2022. PMID: 35361526 Free PMC article. Review.
Protein kinase C as a tumor suppressor.
Newton AC. Newton AC. Semin Cancer Biol. 2018 Feb;48:18-26. doi: 10.1016/j.semcancer.2017.04.017. Epub 2017 May 2. Semin Cancer Biol. 2018. PMID: 28476658 Free PMC article. Review.
PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. Cohen Katsenelson K, et al. Elife. 2019 Aug 13;8:e48609. doi: 10.7554/eLife.48609. Elife. 2019. PMID: 31408005 Free PMC article.
29 results