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Biased Opioid Ligands.
Faouzi A, Varga BR, Majumdar S. Faouzi A, et al. Molecules. 2020 Sep 16;25(18):4257. doi: 10.3390/molecules25184257. Molecules. 2020. PMID: 32948048 Free PMC article. Review.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Opioid signaling and design of analgesics.
Paul B, Sribhashyam S, Majumdar S. Paul B, et al. Prog Mol Biol Transl Sci. 2023;195:153-176. doi: 10.1016/bs.pmbts.2022.06.017. Epub 2022 Aug 5. Prog Mol Biol Transl Sci. 2023. PMID: 36707153 Free PMC article. Review.
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G. Qu Q, et al. Nat Chem Biol. 2023 Apr;19(4):423-430. doi: 10.1038/s41589-022-01208-y. Epub 2022 Nov 21. Nat Chem Biol. 2023. PMID: 36411392 Free PMC article.
Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
Chakraborty S, Uprety R, Slocum ST, Irie T, Le Rouzic V, Li X, Wilson LL, Scouller B, Alder AF, Kruegel AC, Ansonoff M, Varadi A, Eans SO, Hunkele A, Allaoa A, Kalra S, Xu J, Pan YX, Pintar J, Kivell BM, Pasternak GW, Cameron MD, McLaughlin JP, Sames D, Majumdar S. Chakraborty S, et al. J Med Chem. 2021 Nov 25;64(22):16553-16572. doi: 10.1021/acs.jmedchem.1c01111. Epub 2021 Nov 16. J Med Chem. 2021. PMID: 34783240 Free PMC article.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, Le Rouzic V, Eans SO, Simons CA, Hunkele A, Subrath J, Pan YX, Javitch JA, McLaughlin JP, Roth BL, Pasternak GW, Katritch V, Majumdar S. Uprety R, et al. Elife. 2021 Feb 8;10:e56519. doi: 10.7554/eLife.56519. Elife. 2021. PMID: 33555255 Free PMC article.
22 results