R33 CA225498/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	6
2020	3
2021	3
2022	5
2023	7
2024	1

1

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.

Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S. Ye L, et al. Cell Metab. 2022 Apr 5;34(4):595-614.e14. doi: 10.1016/j.cmet.2022.02.009. Epub 2022 Mar 10. Cell Metab. 2022. PMID: 35276062 Free PMC article.

2

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.

Dong MB, Wang G, Chow RD, Ye L, Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen KY, Renauer PA, Du Y, Shen J, Lam SZ, Zhou JJ, Lannin DR, Herbst RS, Chen S. Dong MB, et al. Cell. 2019 Aug 22;178(5):1189-1204.e23. doi: 10.1016/j.cell.2019.07.044. Cell. 2019. PMID: 31442407 Free PMC article.

3

Massively parallel knock-in engineering of human T cells.

Dai X, Park JJ, Du Y, Na Z, Lam SZ, Chow RD, Renauer PA, Gu J, Xin S, Chu Z, Liao C, Clark P, Zhao H, Slavoff S, Chen S. Dai X, et al. Nat Biotechnol. 2023 Sep;41(9):1239-1255. doi: 10.1038/s41587-022-01639-x. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702900 Free PMC article.

4

CTLA-4 tail fusion enhances CAR-T antitumor immunity.

Zhou X, Cao H, Fang SY, Chow RD, Tang K, Majety M, Bai M, Dong MB, Renauer PA, Shang X, Suzuki K, Levchenko A, Chen S. Zhou X, et al. Nat Immunol. 2023 Sep;24(9):1499-1510. doi: 10.1038/s41590-023-01571-5. Epub 2023 Jul 27. Nat Immunol. 2023. PMID: 37500885 Free PMC article.

5

One-step generation of modular CAR-T cells with AAV-Cpf1.

Dai X, Park JJ, Du Y, Kim HR, Wang G, Errami Y, Chen S. Dai X, et al. Nat Methods. 2019 Mar;16(3):247-254. doi: 10.1038/s41592-019-0329-7. Epub 2019 Feb 25. Nat Methods. 2019. PMID: 30804551 Free PMC article.

6

Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function.

Renauer P, Park JJ, Bai M, Acosta A, Lee WH, Lin GH, Zhang Y, Dai X, Wang G, Errami Y, Wu T, Clark P, Ye L, Yang Q, Chen S. Renauer P, et al. Cancer Immunol Res. 2023 Aug 3;11(8):1068-1084. doi: 10.1158/2326-6066.CIR-22-0565. Cancer Immunol Res. 2023. PMID: 37253111 Free PMC article.

7

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade.

Wang G, Chow RD, Zhu L, Bai Z, Ye L, Zhang F, Renauer PA, Dong MB, Dai X, Zhang X, Du Y, Cheng Y, Niu L, Chu Z, Kim K, Liao C, Clark P, Errami Y, Chen S. Wang G, et al. Cancer Discov. 2020 Dec;10(12):1912-1933. doi: 10.1158/2159-8290.CD-19-1448. Epub 2020 Sep 4. Cancer Discov. 2020. PMID: 32887696 Free PMC article.

8

Genome Engineering for Next-Generation Cellular Immunotherapies.

Park JJ, Lee KAV, Lam SZ, Tang K, Chen S. Park JJ, et al. Biochemistry. 2023 Dec 19;62(24):3455-3464. doi: 10.1021/acs.biochem.2c00340. Epub 2022 Aug 5. Biochemistry. 2023. PMID: 35930700 Free PMC article. Review.

9

AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells.

Ye L, Lam SZ, Yang L, Suzuki K, Zou Y, Lin Q, Zhang Y, Clark P, Peng L, Chen S. Ye L, et al. Nat Biomed Eng. 2024 Feb;8(2):132-148. doi: 10.1038/s41551-023-01058-6. Epub 2023 Jul 10. Nat Biomed Eng. 2024. PMID: 37430157 Free PMC article.

10

In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma.

Ye L, Park JJ, Dong MB, Yang Q, Chow RD, Peng L, Du Y, Guo J, Dai X, Wang G, Errami Y, Chen S. Ye L, et al. Nat Biotechnol. 2019 Nov;37(11):1302-1313. doi: 10.1038/s41587-019-0246-4. Epub 2019 Sep 23. Nat Biotechnol. 2019. PMID: 31548728 Free PMC article.

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