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Page 1
Germline variants associated with toxicity to immune checkpoint blockade.
Groha S, Alaiwi SA, Xu W, Naranbhai V, Nassar AH, Bakouny Z, El Zarif T, Saliby RM, Wan G, Rajeh A, Adib E, Nuzzo PV, Schmidt AL, Labaki C, Ricciuti B, Alessi JV, Braun DA, Shukla SA, Keenan TE, Van Allen E, Awad MM, Manos M, Rahma O, Zubiri L, Villani AC, Fairfax B, Hammer C, Khan Z, Reynolds K, Semenov Y, Schrag D, Kehl KL, Freedman ML, Choueiri TK, Gusev A. Groha S, et al. Nat Med. 2022 Dec;28(12):2584-2591. doi: 10.1038/s41591-022-02094-6. Epub 2022 Dec 16. Nat Med. 2022. PMID: 36526723 Free PMC article.
Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.
Baca SC, Singler C, Zacharia S, Seo JH, Morova T, Hach F, Ding Y, Schwarz T, Huang CF, Anderson J, Fay AP, Kalita C, Groha S, Pomerantz MM, Wang V, Linder S, Sweeney CJ, Zwart W, Lack NA, Pasaniuc B, Takeda DY, Gusev A, Freedman ML. Baca SC, et al. Nat Genet. 2022 Sep;54(9):1364-1375. doi: 10.1038/s41588-022-01168-y. Epub 2022 Sep 7. Nat Genet. 2022. PMID: 36071171 Free PMC article.
MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record.
Urbut SM, Yeung MW, Khurshid S, Cho SMJ, Schuermans A, German J, Taraszka K, Fahed AC, Ellinor P, Trinquart L, Parmigiani G, Gusev A, Natarajan P. Urbut SM, et al. medRxiv [Preprint]. 2023 Nov 8:2023.11.08.23298229. doi: 10.1101/2023.11.08.23298229. medRxiv. 2023. Update in: Nat Commun. 2024 Jun 7;15(1):4884. doi: 10.1038/s41467-024-49296-9 PMID: 37986972 Free PMC article. Updated. Preprint.
Allele-Specific QTL Fine Mapping with PLASMA.
Wang AT, Shetty A, O'Connor E, Bell C, Pomerantz MM, Freedman ML, Gusev A. Wang AT, et al. Am J Hum Genet. 2020 Feb 6;106(2):170-187. doi: 10.1016/j.ajhg.2019.12.011. Epub 2020 Jan 30. Am J Hum Genet. 2020. PMID: 32004450 Free PMC article.
Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes.
Gillani R, Camp SY, Han S, Jones JK, Chu H, O'Brien S, Young EL, Hayes L, Mitchell G, Fowler T, Gusev A, Kamihara J, Janeway KA, Schiffman JD, Crompton BD, AlDubayan SH, Van Allen EM. Gillani R, et al. Am J Hum Genet. 2022 Jun 2;109(6):1026-1037. doi: 10.1016/j.ajhg.2022.04.007. Epub 2022 May 4. Am J Hum Genet. 2022. PMID: 35512711 Free PMC article.