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An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues.
J Am Chem Soc. 2008 Jul 23;130(29):9200-1. doi: 10.1021/ja802353j. Epub 2008 Jun 25.
J Am Chem Soc. 2008.
PMID: 18576653
Free PMC article.
Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation.
Garner AL, Yu J, Struss AK, Lowery CA, Zhu J, Kim SK, Park J, Mayorov AV, Kaufmann GF, Kravchenko VV, Janda KD.
Garner AL, et al.
Bioorg Med Chem Lett. 2011 May 1;21(9):2702-5. doi: 10.1016/j.bmcl.2010.11.122. Epub 2010 Dec 4.
Bioorg Med Chem Lett. 2011.
PMID: 21190852
Free PMC article.
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Medicinal chemistry as a conduit for the modulation of quorum sensing.
Lowery CA, Salzameda NT, Sawada D, Kaufmann GF, Janda KD.
Lowery CA, et al.
J Med Chem. 2010 Nov 11;53(21):7467-89. doi: 10.1021/jm901742e.
J Med Chem. 2010.
PMID: 20669927
Free PMC article.
No abstract available.
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