R21 CA217695/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.

Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM. Lake EW, et al. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11894-E11903. doi: 10.1073/pnas.1811158115. Epub 2018 Dec 5. Proc Natl Acad Sci U S A. 2018. PMID: 30518564 Free PMC article.

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. Ruff EF, et al. Elife. 2018 Feb 21;7:e32766. doi: 10.7554/eLife.32766. Elife. 2018. PMID: 29465396 Free PMC article.

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