R21 AI181542/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

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Preclinical and Toxicology Assessment of ALW-II-41-27, an Inhibitor of the Eph Receptor A2 (EphA2).

Kottom TJ, Stelzig KE, Pellegrino MR, Bindzus M, Yi ES, Limper AH. Kottom TJ, et al. Drugs R D. 2024 Sep;24(3):425-434. doi: 10.1007/s40268-024-00483-5. Epub 2024 Aug 6. Drugs R D. 2024. PMID: 39105996 Free PMC article.

Metabolic modulation: Pneumocystis phosphoglucomutase is a target influencing host recognition.

Kottom TJ, Carmona EM, Lepenies B, Limper AH. Kottom TJ, et al. Cell Surf. 2024 Mar 25;11:100123. doi: 10.1016/j.tcsw.2024.100123. eCollection 2024 Jun. Cell Surf. 2024. PMID: 39022598 Free PMC article. Review.

Targeting host tyrosine kinase receptor EphA2 signaling via small-molecule ALW-II-41-27 inhibits macrophage pro-inflammatory signaling responses to Pneumocystis carinii β-glucans.

Kottom TJ, Carmona EM, Limper AH. Kottom TJ, et al. Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0081123. doi: 10.1128/aac.00811-23. Epub 2024 Jan 11. Antimicrob Agents Chemother. 2024. PMID: 38206037 Free PMC article.

Characterization of the Pneumocystis jirovecii and Pneumocystis murina phosphoglucomutases (Pgm2s): a potential target for Pneumocystis therapy.

Kottom TJ, Carmona EM, Limper AH. Kottom TJ, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0075623. doi: 10.1128/aac.00756-23. Epub 2024 Jan 23. Antimicrob Agents Chemother. 2024. PMID: 38259086 Free PMC article.

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