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CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. Epub 2023 Sep 13. Antimicrob Agents Chemother. 2023. PMID: 37702508 Free PMC article.
CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms.
Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. Miron-Ocampo A, et al. bioRxiv [Preprint]. 2023 May 1:2023.05.01.538946. doi: 10.1101/2023.05.01.538946. bioRxiv. 2023. Update in: Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23 PMID: 37205554 Free PMC article. Updated. Preprint.
Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24 PMID: 39257751 Free PMC article. Updated. Preprint.