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Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. Deni I, et al. Cell Chem Biol. 2023 May 18;30(5):470-485.e6. doi: 10.1016/j.chembiol.2023.03.002. Epub 2023 Mar 23. Cell Chem Biol. 2023. PMID: 36963402 Free PMC article.
Validation of Babesia proteasome as a drug target.
Jalovecka M, Hartmann D, Miyamoto Y, Eckmann L, Hajdusek O, O'Donoghue AJ, Sojka D. Jalovecka M, et al. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):394-402. doi: 10.1016/j.ijpddr.2018.08.001. Epub 2018 Aug 7. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30103207 Free PMC article.
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. Bibo-Verdugo B, et al. ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12. ACS Infect Dis. 2019. PMID: 31355632 Free PMC article.
20S Proteasome as a Drug Target in Trichomonas vaginalis.
O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. O'Donoghue AJ, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00448-19. doi: 10.1128/AAC.00448-19. Print 2019 Nov. Antimicrob Agents Chemother. 2019. PMID: 31451503 Free PMC article.
11 results