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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum.
Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. Srikanth S, et al. Nat Immunol. 2019 Feb;20(2):152-162. doi: 10.1038/s41590-018-0287-8. Epub 2019 Jan 14. Nat Immunol. 2019. PMID: 30643259 Free PMC article.
Laminar flow downregulates Notch activity to promote lymphatic sprouting.
Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK. Choi D, et al. J Clin Invest. 2017 Apr 3;127(4):1225-1240. doi: 10.1172/JCI87442. Epub 2017 Mar 6. J Clin Invest. 2017. PMID: 28263185 Free PMC article.