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Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.
Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Matsushima S, et al. Circ Res. 2013 Apr 12;112(8):1135-49. doi: 10.1161/CIRCRESAHA.111.300171. Epub 2013 Mar 8. Circ Res. 2013. PMID: 23476056 Free PMC article.
Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway.
Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Sciarretta S, et al. Circ Res. 2013 Nov 8;113(11):1253-64. doi: 10.1161/CIRCRESAHA.113.301787. Epub 2013 Sep 30. Circ Res. 2013. PMID: 24081881 Free PMC article.