R0I-CA152197/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

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Mechanistic basis for overcoming platinum resistance using copper chelating agents.

Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Liang ZD, et al. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21. Mol Cancer Ther. 2012. PMID: 22914438 Free PMC article.

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.

Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, Kuo MT. Tsai WB, et al. Cancer Res. 2012 May 15;72(10):2622-33. doi: 10.1158/0008-5472.CAN-11-3605. Epub 2012 Mar 29. Cancer Res. 2012. PMID: 22461507 Free PMC article.

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