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Fine-tuning multiprotein complexes using small molecules.
Thompson AD, Dugan A, Gestwicki JE, Mapp AK. Thompson AD, et al. ACS Chem Biol. 2012 Aug 17;7(8):1311-20. doi: 10.1021/cb300255p. Epub 2012 Jul 23. ACS Chem Biol. 2012. PMID: 22725693 Free PMC article. Review.
Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.
Majmudar CY, Højfeldt JW, Arevang CJ, Pomerantz WC, Gagnon JK, Schultz PJ, Cesa LC, Doss CH, Rowe SP, Vásquez V, Tamayo-Castillo G, Cierpicki T, Brooks CL 3rd, Sherman DH, Mapp AK. Majmudar CY, et al. Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11258-62. doi: 10.1002/anie.201206815. Epub 2012 Oct 8. Angew Chem Int Ed Engl. 2012. PMID: 23042634 Free PMC article.