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Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal.
J Biol Chem. 2008 Feb 22;283(8):4490-500. doi: 10.1074/jbc.M704960200. Epub 2007 Dec 18.
J Biol Chem. 2008.
PMID: 18089557
Free article.
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.
Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC.
Shani G, et al.
Mol Cell Biol. 2008 Jan;28(2):666-77. doi: 10.1128/MCB.01716-07. Epub 2007 Nov 8.
Mol Cell Biol. 2008.
PMID: 17991893
Free PMC article.
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Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.
Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, Gray PC.
Kelber JA, et al.
Oncogene. 2009 Jun 18;28(24):2324-36. doi: 10.1038/onc.2009.97. Epub 2009 May 4.
Oncogene. 2009.
PMID: 19421146
Free PMC article.
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