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Synthetic CRISPR RNA-Cas9-guided genome editing in human cells.
Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. Rahdar M, et al. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7110-7. doi: 10.1073/pnas.1520883112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26589814 Free PMC article.
Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.
Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. Israelson A, et al. Neuron. 2015 Apr 8;86(1):218-32. doi: 10.1016/j.neuron.2015.02.034. Epub 2015 Mar 19. Neuron. 2015. PMID: 25801706 Free PMC article.
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.
Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW. Sun S, et al. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6993-7002. doi: 10.1073/pnas.1520639112. Epub 2015 Nov 30. Proc Natl Acad Sci U S A. 2015. PMID: 26621731 Free PMC article.