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2021 3
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Page 1
Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Krishna Kumar K, et al. Nature. 2024 May;629(8013):951-956. doi: 10.1038/s41586-024-07327-x. Epub 2024 Apr 17. Nature. 2024. PMID: 38632403
Step-wise activation of a Family C GPCR.
Kumar KK, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK. Kumar KK, et al. bioRxiv [Preprint]. 2023 Aug 30:2023.08.29.555158. doi: 10.1101/2023.08.29.555158. bioRxiv. 2023. PMID: 37693614 Free PMC article. Preprint.
Drug discovery in the era of cryo-electron microscopy.
Robertson MJ, Meyerowitz JG, Skiniotis G. Robertson MJ, et al. Trends Biochem Sci. 2022 Feb;47(2):124-135. doi: 10.1016/j.tibs.2021.06.008. Epub 2021 Jul 16. Trends Biochem Sci. 2022. PMID: 34281791 Free PMC article. Review.
G-protein activation by a metabotropic glutamate receptor.
Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G. Seven AB, et al. Nature. 2021 Jul;595(7867):450-454. doi: 10.1038/s41586-021-03680-3. Epub 2021 Jun 30. Nature. 2021. PMID: 34194039 Free PMC article.
Asymmetric activation of the calcium-sensing receptor homodimer.
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G. Gao Y, et al. Nature. 2021 Jul;595(7867):455-459. doi: 10.1038/s41586-021-03691-0. Epub 2021 Jun 30. Nature. 2021. PMID: 34194040 Free PMC article.
Small vs. Large Library Docking for Positive Allosteric Modulators of the Calcium Sensing Receptor.
Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Levit Kaplan A, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G. Liu F, et al. bioRxiv [Preprint]. 2024 Mar 6:2023.12.27.573448. doi: 10.1101/2023.12.27.573448. bioRxiv. 2024. Update in: Science. 2024 Sep 20;385(6715):eado1868. doi: 10.1126/science.ado1868 PMID: 38234749 Free PMC article. Updated. Preprint.