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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.
Park JH, Hothi P, Lopez Garcia de Lomana A, Pan M, Calder R, Turkarslan S, Wu WJ, Lee H, Patel AP, Cobbs C, Huang S, Baliga NS. Park JH, et al. bioRxiv [Preprint]. 2024 Feb 7:2024.02.02.578510. doi: 10.1101/2024.02.02.578510. bioRxiv. 2024. Update in: Sci Adv. 2024 Jun 7;10(23):eadj7706. doi: 10.1126/sciadv.adj7706 PMID: 38370784 Free PMC article. Updated. Preprint.
Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities.
Herman JA, Romain RR, Hoellerbauer P, Shirnekhi HK, King DC, DeLuca KF, Osborne Nishimura E, Paddison PJ, DeLuca JG. Herman JA, et al. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208255119. doi: 10.1073/pnas.2208255119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191188 Free PMC article.
Revealing the biology behind MRI signatures in high grade glioma.
Lewis EM, Mao L, Wang L, Swanson KR, Barajas RF, Li J, Tran NL, Hu LS, Plaisier CL. Lewis EM, et al. medRxiv [Preprint]. 2023 Dec 15:2023.12.08.23299733. doi: 10.1101/2023.12.08.23299733. medRxiv. 2023. PMID: 38168377 Free PMC article. Preprint.
Functional genomic analysis of adult and pediatric brain tumor isolates.
Hoellerbauer P, Biery MC, Arora S, Rao Y, Girard EJ, Mitchell K, Dighe P, Kufeld M, Kuppers DA, Herman JA, Holland EC, Soroceanu L, Vitanza NA, Olson JM, Pritchard JR, Paddison PJ. Hoellerbauer P, et al. bioRxiv [Preprint]. 2023 Jan 6:2023.01.05.522885. doi: 10.1101/2023.01.05.522885. bioRxiv. 2023. PMID: 36711964 Free PMC article. Preprint.
15 results