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The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. Wang Q, et al. Mol Psychiatry. 2011 Oct;16(10):1006-23. doi: 10.1038/mp.2010.87. Epub 2010 Sep 14. Mol Psychiatry. 2011. PMID: 20838393 Free PMC article.
Ube3a is required for experience-dependent maturation of the neocortex.
Yashiro K, Riday TT, Condon KH, Roberts AC, Bernardo DR, Prakash R, Weinberg RJ, Ehlers MD, Philpot BD. Yashiro K, et al. Nat Neurosci. 2009 Jun;12(6):777-83. doi: 10.1038/nn.2327. Epub 2009 May 10. Nat Neurosci. 2009. PMID: 19430469 Free PMC article.