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Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies.
D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P. D'Amario D, et al. Circ Res. 2011 Apr 1;108(7):857-61. doi: 10.1161/CIRCRESAHA.111.241380. Epub 2011 Feb 17. Circ Res. 2011. PMID: 21330601 Free PMC article.
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function.
Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J. Rota M, et al. Circ Res. 2008 Jul 3;103(1):107-16. doi: 10.1161/CIRCRESAHA.108.178525. Epub 2008 Jun 12. Circ Res. 2008. PMID: 18556576 Free PMC article.