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Page 1
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA. Asher WB, et al. Cell. 2022 May 12;185(10):1661-1675.e16. doi: 10.1016/j.cell.2022.03.042. Epub 2022 Apr 27. Cell. 2022. PMID: 35483373 Free PMC article.
Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin.
Kahsai AW, Shah KS, Shim PJ, Lee MA, Shreiber BN, Schwalb AM, Zhang X, Kwon HY, Huang LY, Soderblom EJ, Ahn S, Lefkowitz RJ. Kahsai AW, et al. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2303794120. doi: 10.1073/pnas.2303794120. Epub 2023 Oct 16. Proc Natl Acad Sci U S A. 2023. PMID: 37844230 Free PMC article.
Recent developments in biased agonism.
Wisler JW, Xiao K, Thomsen AR, Lefkowitz RJ. Wisler JW, et al. Curr Opin Cell Biol. 2014 Apr;27:18-24. doi: 10.1016/j.ceb.2013.10.008. Epub 2013 Nov 20. Curr Opin Cell Biol. 2014. PMID: 24680426 Free PMC article. Review.
109 results