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Page 1
Membrane transporters in drug development and as determinants of precision medicine.
Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM. Galetin A, et al. Nat Rev Drug Discov. 2024 Apr;23(4):255-280. doi: 10.1038/s41573-023-00877-1. Epub 2024 Jan 24. Nat Rev Drug Discov. 2024. PMID: 38267543 Free PMC article. Review.
Genomewide Association Studies in Pharmacogenomics.
McInnes G, Yee SW, Pershad Y, Altman RB. McInnes G, et al. Clin Pharmacol Ther. 2021 Sep;110(3):637-648. doi: 10.1002/cpt.2349. Epub 2021 Jul 18. Clin Pharmacol Ther. 2021. PMID: 34185318 Free PMC article. Review.
Emerging Roles of the Human Solute Carrier 22 Family.
Yee SW, Giacomini KM. Yee SW, et al. Drug Metab Dispos. 2021 Dec 17;50(9):1193-210. doi: 10.1124/dmd.121.000702. Online ahead of print. Drug Metab Dispos. 2021. PMID: 34921098 Free PMC article.
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. Yee SW, et al. Res Sq [Preprint]. 2023 Sep 14:rs.3.rs-3263845. doi: 10.21203/rs.3.rs-3263845/v1. Res Sq. 2023. Update in: Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7 PMID: 37790518 Free PMC article. Updated. Preprint.
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.
Yee SW, Ferrández-Peral L, Alentorn-Moron P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Wolfreys FD, Yang J, Gestwicki JE, Capra JA, Artursson P, Newman JW, Marquès-Bonet T, Giacomini KM. Yee SW, et al. Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7. Nat Commun. 2024. PMID: 38782905 Free PMC article.
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. Yee SW, et al. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543963. doi: 10.1101/2023.06.06.543963. bioRxiv. 2023. Update in: Mol Cell. 2024 May 16;84(10):1932-1947.e10. doi: 10.1016/j.molcel.2024.04.008 PMID: 37333090 Free PMC article. Updated. Preprint.
Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates.
Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. Yee SW, et al. bioRxiv [Preprint]. 2023 Aug 12:2023.08.08.552553. doi: 10.1101/2023.08.08.552553. bioRxiv. 2023. Update in: Nat Commun. 2024 May 23;15(1):4380. doi: 10.1038/s41467-024-48569-7 PMID: 37609337 Free PMC article. Updated. Preprint.