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Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition.
Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ. Gliech CR, et al. EMBO J. 2024 Mar;43(5):666-694. doi: 10.1038/s44318-024-00031-6. Epub 2024 Jan 26. EMBO J. 2024. PMID: 38279026 Free PMC article.
TRIM37: a critical orchestrator of centrosome function.
Domínguez-Calvo A, Gönczy P, Holland AJ, Balestra FR. Domínguez-Calvo A, et al. Cell Cycle. 2021 Dec;20(23):2443-2451. doi: 10.1080/15384101.2021.1988289. Epub 2021 Oct 21. Cell Cycle. 2021. PMID: 34672905 Free PMC article. Review.
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Yeow ZY, Lambrus BG, Marlow R, Zhan KH, Durin MA, Evans LT, Scott PM, Phan T, Park E, Ruiz LA, Moralli D, Knight EG, Badder LM, Novo D, Haider S, Green CM, Tutt ANJ, Lord CJ, Chapman JR, Holland AJ. Yeow ZY, et al. Nature. 2020 Sep;585(7825):447-452. doi: 10.1038/s41586-020-2690-1. Epub 2020 Sep 9. Nature. 2020. PMID: 32908313 Free PMC article.
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