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A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Wang P, Lis JT, Feschotte C, Erzurum SC, Cheng F, Yu H. Zhou Y, et al. Nat Biotechnol. 2023 Jan;41(1):128-139. doi: 10.1038/s41587-022-01474-0. Epub 2022 Oct 10. Nat Biotechnol. 2023. PMID: 36217030 Free PMC article.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Trepte P, Secker C, Olivet J, Blavier J, Kostova S, Maseko SB, Minia I, Silva Ramos E, Cassonnet P, Golusik S, Zenkner M, Beetz S, Liebich MJ, Scharek N, Schütz A, Sperling M, Lisurek M, Wang Y, Spirohn K, Hao T, Calderwood MA, Hill DE, Landthaler M, Choi SG, Twizere JC, Vidal M, Wanker EE. Trepte P, et al. Mol Syst Biol. 2024 Apr;20(4):428-457. doi: 10.1038/s44320-024-00019-8. Epub 2024 Mar 11. Mol Syst Biol. 2024. PMID: 38467836 Free PMC article.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Trepte P, Secker C, Kostova S, Maseko SB, Choi SG, Blavier J, Minia I, Ramos ES, Cassonnet P, Golusik S, Zenkner M, Beetz S, Liebich MJ, Scharek N, Schütz A, Sperling M, Lisurek M, Wang Y, Spirohn K, Hao T, Calderwood MA, Hill DE, Landthaler M, Olivet J, Twizere JC, Vidal M, Wanker EE. Trepte P, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544560. doi: 10.1101/2023.06.14.544560. bioRxiv. 2023. Update in: Mol Syst Biol. 2024 Apr;20(4):428-457. doi: 10.1038/s44320-024-00019-8 PMID: 37398436 Free PMC article. Updated. Preprint.
Assessment of community efforts to advance network-based prediction of protein-protein interactions.
Wang XW, Madeddu L, Spirohn K, Martini L, Fazzone A, Becchetti L, Wytock TP, Kovács IA, Balogh OM, Benczik B, Pétervári M, Ágg B, Ferdinandy P, Vulliard L, Menche J, Colonnese S, Petti M, Scarano G, Cuomo F, Hao T, Laval F, Willems L, Twizere JC, Vidal M, Calderwood MA, Petrillo E, Barabási AL, Silverman EK, Loscalzo J, Velardi P, Liu YY. Wang XW, et al. Nat Commun. 2023 Mar 22;14(1):1582. doi: 10.1038/s41467-023-37079-7. Nat Commun. 2023. PMID: 36949045 Free PMC article.
A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19.
Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Lis JT, Feschotte C, Erzurum SC, Cheng F, Yu H. Zhou Y, et al. Res Sq [Preprint]. 2022 Jun 7:rs.3.rs-1354127. doi: 10.21203/rs.3.rs-1354127/v2. Res Sq. 2022. Update in: Nat Biotechnol. 2023 Jan;41(1):128-139. doi: 10.1038/s41587-022-01474-0 PMID: 35677070 Free PMC article. Updated. Preprint.