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PHLiPPing the switch on Akt and protein kinase C signaling.
Brognard J, Newton AC. Brognard J, et al. Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. Trends Endocrinol Metab. 2008. PMID: 18511290 Free PMC article. Review.
PHLPP-1 negatively regulates Akt activity and survival in the heart.
Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. Miyamoto S, et al. Circ Res. 2010 Aug 20;107(4):476-84. doi: 10.1161/CIRCRESAHA.109.215020. Epub 2010 Jun 24. Circ Res. 2010. PMID: 20576936 Free PMC article.