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Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington's disease.
Pepe G, Capocci L, Marracino F, Realini N, Lenzi P, Martinello K, Bovier TF, Bichell TJ, Scarselli P, Di Cicco C, Bowman AB, Digilio FA, Fucile S, Fornai F, Armirotti A, Parlato R, Di Pardo A, Maglione V. Pepe G, et al. Mol Ther. 2023 Jan 4;31(1):282-299. doi: 10.1016/j.ymthe.2022.09.004. Epub 2022 Sep 16. Mol Ther. 2023. PMID: 36116006 Free PMC article.
Cellular fura-2 manganese extraction assay (CFMEA).
Kwakye GF, Li D, Kabobel OA, Bowman AB. Kwakye GF, et al. Curr Protoc Toxicol. 2011 May;Chapter 12:Unit12.18. doi: 10.1002/0471140856.tx1218s48. Curr Protoc Toxicol. 2011. PMID: 21553393 Free PMC article.
Brain manganese and the balance between essential roles and neurotoxicity.
Balachandran RC, Mukhopadhyay S, McBride D, Veevers J, Harrison FE, Aschner M, Haynes EN, Bowman AB. Balachandran RC, et al. J Biol Chem. 2020 May 8;295(19):6312-6329. doi: 10.1074/jbc.REV119.009453. Epub 2020 Mar 18. J Biol Chem. 2020. PMID: 32188696 Free PMC article. Review.
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB. Bichell TJV, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1596-1604. doi: 10.1016/j.bbadis.2017.02.013. Epub 2017 Feb 16. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28213125 Free PMC article.
63 results